ID A0A1A5X3Z9_9BACL Unreviewed; 260 AA.
AC A0A1A5X3Z9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Precorrin-4 C(11)-methyltransferase {ECO:0000313|EMBL:OBR48059.1};
DE EC=2.1.1.133 {ECO:0000313|EMBL:UYZ12813.1};
GN Name=cobM {ECO:0000313|EMBL:UYZ12813.1};
GN ORFNames=A6764_16835 {ECO:0000313|EMBL:OBR48059.1}, A6764_18705
GN {ECO:0000313|EMBL:UYZ12813.1};
OS Brevibacillus sp. WF146.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=319501 {ECO:0000313|EMBL:OBR48059.1};
RN [1] {ECO:0000313|EMBL:OBR48059.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WF146 {ECO:0000313|EMBL:OBR48059.1};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:UYZ12813.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WF146 {ECO:0000313|EMBL:UYZ12813.1};
RA Tang B., Tang X.-F., Zhu F., Li Y.;
RT "Complete genome sequence of Brevibacillus thermoruber WF146.";
RL Submitted (OCT-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879, ECO:0000256|RuleBase:RU003960}.
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DR EMBL; LXGJ01000256; OBR48059.1; -; Genomic_DNA.
DR EMBL; CP109943; UYZ12813.1; -; Genomic_DNA.
DR RefSeq; WP_035300771.1; NZ_LXGJ01000256.1.
DR AlphaFoldDB; A0A1A5X3Z9; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000093585; Chromosome.
DR GO; GO:0046026; F:precorrin-4 C11-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11641; Precorrin-4_C11-MT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006362; Cbl_synth_CobM/CibF.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01465; cobM_cbiF; 1.
DR PANTHER; PTHR45790:SF4; COBALT-PRECORRIN-4 C(11)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Reference proteome {ECO:0000313|Proteomes:UP000093585};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 2..208
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 260 AA; 28201 MW; 4F6ACB1BDB955C15 CRC64;
MKLYIVGAGP GDPDLITVKG LKLLQQADVV LYTDSLVSDE LAAKAKPGAE VLQSSGMALE
EMVELMVDRV RQGKTVVRLH TGDPSVYGAT MEQIALLKRA GIDVEIVPGV SSVFAAAAAL
GAELTIPELT QTLILTRAEG RTPVPEREKL RALAEHHCTI ALFLSATLTK KVVRELTEAG
WSEDTPVAVV QRASWPDQVI VRTTLKHLDE EMGKHGIRSH AMILAGWALD PAIHEKSGQH
RSKLYDKTFT HGYRKGVTEG
//
