ID A0A1A5ZYK6_9TREE Unreviewed; 1673 AA.
AC A0A1A5ZYK6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rho guanyl-nucleotide exchange factor {ECO:0000313|EMBL:OBR82878.1};
GN ORFNames=I303_06435 {ECO:0000313|EMBL:OBR82878.1};
OS Kwoniella dejecticola CBS 10117.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296121 {ECO:0000313|EMBL:OBR82878.1, ECO:0000313|Proteomes:UP000078595};
RN [1] {ECO:0000313|EMBL:OBR82878.1, ECO:0000313|Proteomes:UP000078595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10117 {ECO:0000313|EMBL:OBR82878.1,
RC ECO:0000313|Proteomes:UP000078595};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus dejecticola CBS10117.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI894034; OBR82878.1; -; Genomic_DNA.
DR RefSeq; XP_018260720.1; XM_018409717.1.
DR STRING; 1296121.A0A1A5ZYK6; -.
DR GeneID; 28970134; -.
DR VEuPathDB; FungiDB:I303_06435; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000078595; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000078595}.
FT DOMAIN 854..1041
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1076..1221
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1247..1544
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1561..1620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1650..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..101
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..202
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1570..1590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1597..1613
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1673 AA; 182919 MW; B1B37D0145CFE254 CRC64;
MPPSGPRSRP AGPQQSGRAP PSANQRNEVF ENIFGRPAGG HHLGQGPSHN TAPSAAGPSH
LHPSYAPQAP PSGYLNPAQP SYPPGTSYTS HPPPPRQQFP PHHTYQPAAN PNGGGYSGQY
DASNGPGNGT YGRKVSQGYA SSAYGVPAGD LPDRRASMAP STYSTTSSAL YYSPNPDTVS
PPPPRTNRLP SNPNPIFPTP APAHSGRIPS GSGPGPLRQQ GLTPAQAYQA SASQNYSNGN
ANLASPASGV FPHRGASPAP PLPNPKSDSP ASFASSSHTS SRLPTSTSTT SFHKPLSQQS
PPPPPLPKSA YGGIDETESH TSGATGSDFI GQALGKLAFE TSPQKGLLDD FGLSSSAGSH
SNQDYFPRQS DPHAPPIPPK AEQRHGSFSS NSGASMHKRM ASDSSITSSV YTTTAGRAHM
TPLSQIEPPS VGHESFSSPT TPTGSDSGFA AHAQRRLSGR KSMDSTVSLP LPASDSPLPP
GAAPSATAFD ARATSFSGSS TTRKDVVKSM RSESIGHGAQ RKSNPANAPP SSFSFPTPLS
SQRSLSGTLT RSTSTARAAI LQSLPPIYPA MLSQVADAFK KLLVLSELVK DGITYKDSFD
GRTAVGIIAD IIKTPDRNLA LLLGRALDNQ KFFHDVTYDH RLRDNPHEIY QFKERLTAVP
FMGSAAQDSP LSEHAGLGRT SSVGSTNPRS SGMGMTRPPI GGQGNSDSGS MNNTSDSGHL
PPSSINAHST PATSTTTLAS PKSMTKSHQW DSLPGLGNSE KIQGEDESED DLPVGVFTLL
TDCYSPTCSR ERLCYSINCP RRLEQMKRLN MKPQGGLSRK LSQESIVDVK ETGTLWIHSV
SQEILDSVDD TEKKRQEAIN EVIYTERDFV RDLEYLRDSW VKPLRTSDVI DPKRRDDFVR
QVFWNVHDVL GVNQVLAEKL TKRQKKEPVV SGIGDLFLER VPLFEPFVVY GSHQLFGKYE
FEKEKTANPN FQKFVDETER KPESRKLELN GYLTKPTTRL GRYPLLLEAV LKYTPEDHPD
KKILPEVIKL VKGYLTKVNI ESGKSENIFE LAQIEQSLVF RPGEQIDLRL RDKSRELVHK
GPLKRRGGNR EDIADLLGFL FDHAFLLVKP KWVQKSEQYK VYRRPIPLEL LVLVTPDDSY
NSSKLSASRA ANKLMPRQSN TSSISGNAKT NALAHPPKPE SKHGFSLTVI HLGKKGYSMQ
LWVDTYMSRK KWLESIDKQQ TILRDRSCVF VSETITEGGS SFTGGGLRKV NCVSPYDMGH
RMIYGTDEGV YFSNLRDDKL REPIKVINLL DVTQVDVIEE FQLLIVLHER CVTTFPLDCL
DPNDANAALK RGKRISSHTS FIKSGVCLGK TLIAIVKSST LSSTIKVMEP IDQSMRGKKA
PGGFMKRLNG RDDVLKLFKE FYIPTESSSV HFLKTKLCVG CTKGFEIVDL ETLDMQGLLD
PSDASLDFVL KRDNVRPIAI YRIEEDFLLC YDEFAFYVNK NGWRSRPKWA IVWEGLPTAF
ALQYPYVIAF EPTFIEVHHV ETGHLVQIIP GSNIQCLFAD TPPSRVNAPV PIQANRGLMY
PPQNNGPYGR PPPQSTQSLH QQQQGYFPSQ AVPGQAGFRP RPPPGPGHSY GNMPPPPLQQ
QGMMVSRFAR QQVIFTSDDS HVQFLKFPPP QQQQHRAAGQ QVVMGSGHSM RHQ
//
