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Database: UniProt
Entry: A0A1A6A7H1_9TREE
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ID   A0A1A6A7H1_9TREE        Unreviewed;       879 AA.
AC   A0A1A6A7H1;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=Phosphatidylinositol 3-kinase VPS34 {ECO:0000256|ARBA:ARBA00041128, ECO:0000256|PIRNR:PIRNR000587};
DE            EC=2.7.1.137 {ECO:0000256|ARBA:ARBA00012073, ECO:0000256|PIRNR:PIRNR000587};
GN   ORFNames=I303_03720 {ECO:0000313|EMBL:OBR86004.1};
OS   Kwoniella dejecticola CBS 10117.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Kwoniella.
OX   NCBI_TaxID=1296121 {ECO:0000313|EMBL:OBR86004.1, ECO:0000313|Proteomes:UP000078595};
RN   [1] {ECO:0000313|EMBL:OBR86004.1, ECO:0000313|Proteomes:UP000078595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 10117 {ECO:0000313|EMBL:OBR86004.1,
RC   ECO:0000313|Proteomes:UP000078595};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA   Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA   Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Cryptococcus dejecticola CBS10117.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC         1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP +
CC         H(+); Xref=Rhea:RHEA:12709, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57880, ChEBI:CHEBI:58088, ChEBI:CHEBI:456216;
CC         EC=2.7.1.137; Evidence={ECO:0000256|ARBA:ARBA00023985};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12710;
CC         Evidence={ECO:0000256|ARBA:ARBA00023985};
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR   EMBL; KI894030; OBR86004.1; -; Genomic_DNA.
DR   RefSeq; XP_018263846.1; XM_018407038.1.
DR   AlphaFoldDB; A0A1A6A7H1; -.
DR   STRING; 1296121.A0A1A6A7H1; -.
DR   GeneID; 28967419; -.
DR   VEuPathDB; FungiDB:I303_03720; -.
DR   OrthoDB; 10350at2759; -.
DR   Proteomes; UP000078595; Unassembled WGS sequence.
DR   GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd08397; C2_PI3K_class_III; 1.
DR   CDD; cd00896; PI3Kc_III; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR002420; PI3K-type_C2_dom.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR008290; PI3K_Vps34.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF7; PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00792; PI3K_C2; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   PIRSF; PIRSF000587; PI3K_Vps34; 1.
DR   SMART; SM00142; PI3K_C2; 1.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51547; C2_PI3K; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000587};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000587};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000587};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078595};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000587}.
FT   DOMAIN          19..188
FT                   /note="C2 PI3K-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51547"
FT   DOMAIN          303..504
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          581..865
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   REGION          243..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   879 AA;  99636 MW;  610DC92C7468FF27 CRC64;
     MQADPSRDKD YSFASLCDLK SHVTLKINSL EGNIPRRSYS DSLKDTDLLH AGLQHDGPSD
     LYITCQLWAN GIQYTLPFRT AWKDFPKGYI WNQTIILPIT YPSLLLTSQI TFTIWDCHGA
     GKAVPVGGTT MNLFTSKRTL KRGQQRLYVH RDVEADPKPY TSTPSELLGE AEDEMGRLER
     LVKEFERGDI VKIDWLDRIA FRQIEKAHAA ESSKSDKLYL YVDLPKFDFP VVYSEQESSI
     PLPPAPIPHP LPQSQQQISG VPPQLLSTDP HLWRTYDPDA WRENPVEIKH RKLLRSQRLG
     DEGRDLKPGP AERDRLNEIF RLPPTASLSA IDKDLLWKFR FSLFRSPRSL TKFLKCVTWS
     DPVEAKQAVE KLLPLWGQEV GMDDALELLG PGFVDKRVRS FAVKRLQRAD DEELLLYLLQ
     LVQALKFDML TSMTDSMRGS RHRKRDAAAK ADEGESGLSQ FLIDRSVANP VLGTSFHWYL
     MIECDANQPS GKMYAKVAFT FQTRLSETAE GIAQRDVLKR QGQLVEALSA RSKEIRSSKD
     SRSKKIEKLK AFLGDSKHNM SPLPAPLPLP LNARVSVTSV TPDKSSVFKS NLLPLLIWFE
     TTDFTRQTED ESSETPISIT PDYPIIFKNG DDLRQDQLVI QLFTLMDRLL RKENLDLKLS
     PYSVLATSKT EGMVQFVPSK SLAAIMAEFG SLQNYLRQEH ADDGALGSYG IETGVMDTFV
     RSCAGYSVLT YVLGVGDRHL DNLMLAPDGH FFHVDFGYIL GRDPKPYPPP VKVCKEMVDA
     MGGTQSSHYA RFQSLCYTAF IGLRKNANLI LNLVALMVDA GIQDIQYEPD KAVWKVQEKF
     MLDLSEEDAI KQFEALLNDT SYLNMMFDRI HDLAQYLRD
//
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