ID A0A1A6C8U5_9GAMM Unreviewed; 720 AA.
AC A0A1A6C8U5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN ORFNames=Thpro_020686 {ECO:0000313|EMBL:OBS10970.1};
OS Acidihalobacter prosperus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Acidihalobacter.
OX NCBI_TaxID=160660 {ECO:0000313|EMBL:OBS10970.1, ECO:0000313|Proteomes:UP000029273};
RN [1] {ECO:0000313|EMBL:OBS10970.1, ECO:0000313|Proteomes:UP000029273}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5130 {ECO:0000313|EMBL:OBS10970.1,
RC ECO:0000313|Proteomes:UP000029273};
RX PubMed=25342676;
RA Ossandon F.J., Cardenas J.P., Corbett M., Quatrini R., Holmes D.S.,
RA Watkin E.;
RT "Draft Genome Sequence of the Iron-Oxidizing, Acidophilic, and Halotolerant
RT 'Thiobacillus prosperus' Type Strain DSM 5130.";
RL Genome Announc. 2:0-0(2014).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS10970.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JQSG02000001; OBS10970.1; -; Genomic_DNA.
DR RefSeq; WP_038086682.1; NZ_JQSG02000001.1.
DR AlphaFoldDB; A0A1A6C8U5; -.
DR STRING; 160660.BJI67_06670; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000029273; Unassembled WGS sequence.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF40; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000029273}.
FT DOMAIN 390..453
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 646..720
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 548..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 81340 MW; A1EAF6A75776E268 CRC64;
MKPNETTPAD PPPDDAERLS ERLLEAVGEQ RRGQMAQALS HLTEAGARER KRPDGRAAAL
RLLEMGADGD SVVAAVLADP RLRDRLSPEY LTQTYGATMA SLVRNIHWLN TFKECREEFV
QPPEQAEHLR RMLLAMVDDV RAVLVKLAYR VERLHLLAEE SYETRRCIAR ETLDIYAPLA
NRLGLGQLKW ALEDLAFRYL EPQTYKRLAK SLEETRDSRE RYVSAFVDEL RAALQAEGIE
AETYGRPKHI YSIYKKISRK NIDLNDLYDI RAVRVLVDRV STCYAVLGVV HGRWTHIPKE
FDDYIANRKE NGYQSLHTAV IGPEGKVVEV QIRTHEMHAL AEQGVAAHWR YKEGGRQDEA
LDKAVNSLRN LLEHRDNDEE LLESFHAELF GDRVFVLTPR GDVLDLPKGA TPLDFAYTVH
SEVGHRCRGA KVDGRIVPLS YTLKSGEQVE ILTAREPNPS RDWYNPNTGY LYSARNRAKV
RHWFAQLDRD QHLADGRAIL EREAQRLGTP VPDLEVLVRR FHVQTPDELL LAIGRGDVRP
GQIASALQGP QAPASLPADG VRKAPSHGGR PDRDAIRVQG VGNLLTQFAQ CCKPAPGDPV
VGYITKGEGV TIHRSDCPNV LNMPDTQRKR LIEADWGERP HSYPVDIHIE AFDRQGLLRD
ITQTLTNEKI NVLAANTRTN RDDQSVIMDL EVEIVDIAQL SRILDKLGQL PNVISAERKH
//
