ID A0A1A6FWL8_NEOLE Unreviewed; 992 AA.
AC A0A1A6FWL8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN ORFNames=A6R68_10908 {ECO:0000313|EMBL:OBS57974.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS57974.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS57974.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS57974.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS57974.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS57974.1}.
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DR EMBL; LZPO01116982; OBS57974.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6FWL8; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 2.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 555..573
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 593..612
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 641..659
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 679..695
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 741..760
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 766..786
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 813..830
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 836..853
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 75..304
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 327..384
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT DOMAIN 385..819
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 111441 MW; 09DEBA87AF3E2FED CRC64;
MSRWTRGTLC TPPSGTPGRS RDEGSPAAEQ LQDILGEEDE APNPTLFTEM DTLQHDGDQM
EWKESARWIK FEEKVEEGGE RWSKPHVSTL SLHSLFELRT CLQTGTVLLD LDSGSLPQII
DDVIEKQIED GLLRPELRER VSYVLLRKHR HQTKKPIHLS LADIGKSVST THRSSARSPP
AGPTLHRSTE DLRMRQSTSY GHLCHAQSRS MNDISHTPNT DQRKNKXMKK IPKDSEASNV
LVGEVDFLDQ PFIAFVRLVQ SAMLGGVTEV PVPTRFLFIL LGPSGRAKSY NEIGRAIATL
MVDDGLEASL PLLVSAEESS LLPVSSRFFG GLRLDVKRKL PWFPSDFYDG FHIQSVSAVL
FIYLGCITNA ITFGGLLGDA TDNYQPLIIL SSTGPILIFE KLLFDFSKAN GLDYMEFRLW
IGLHSAIQCL ILVATDASFI IKYITRFTEE GFSTLISFIF IYDAIKKMIG AFSYYPINTD
FKPDSITTYK CECVAPDTVN TTTVNVSAPL APNTNTSLPS AFPNNALDWS LLSKKECLSY
GGRLLGNSCR FIPDLALMSF ILFFGTYSMT LTLKKFKFSR YFPTKVRTLV ADFSIVFSIL
LFCGIDACFG LQTPKLHVPN VIKPTRPDRG WFVAPFGKNP WWVYPASILP ALLVTILIFM
DQQITAVIVN RKENKLKKAA GYHLDLFWVG ILMALCSFTG LPWYVAATVI SIAHIDSLKM
ETETSAPGEQ PQFLGVREQR VTGILVFILT GISVFLAPIL KYIPMPVLYG VFLYMGVASL
NGIQFWERCK LFLMPAKHQP DHAFLRHVPL RRIHLFTLVQ ILCLALLWIL KSTMAAIIFP
VMILGLIIVR RLLDLIFSQH DLAWIDNILP EKEKQETDKK KKRRKGVHEN TDEEIKLFGV
TFLAEFLPDS WVSTTVCYCA MVPLWAQVFA AALTTWSGIT LHFKISCPAS PAFSYSRSPV
FMVPQVKIEM EPDLDFTDNE DYGREVGGET TL
//