ID   A0A1A6FXH8_NEOLE        Unreviewed;       538 AA.
AC   A0A1A6FXH8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   13-SEP-2023, entry version 30.
DE   RecName: Full=MAGUK p55 subfamily member 2 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=A6R68_10288 {ECO:0000313|EMBL:OBS58628.1};
OS   Neotoma lepida (Desert woodrat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Neotominae; Neotoma.
OX   NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS58628.1, ECO:0000313|Proteomes:UP000092124};
RN   [1] {ECO:0000313|EMBL:OBS58628.1, ECO:0000313|Proteomes:UP000092124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=417 {ECO:0000313|EMBL:OBS58628.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:OBS58628.1};
RA   Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT   "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT   lepida.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MAGUK family.
CC       {ECO:0000256|ARBA:ARBA00007014}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBS58628.1}.
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DR   EMBL; LZPO01115350; OBS58628.1; -; Genomic_DNA.
DR   STRING; 56216.A0A1A6FXH8; -.
DR   Proteomes; UP000092124; Unassembled WGS sequence.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd12037; SH3_MPP2; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 1.10.287.650; L27 domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR014775; L27_C.
DR   InterPro; IPR004172; L27_dom.
DR   InterPro; IPR036892; L27_dom_sf.
DR   InterPro; IPR035602; MPP2_SH3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23122:SF35; MAGUK P55 SUBFAMILY MEMBER 2; 1.
DR   PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF02828; L27; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00569; L27; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF101288; L27 domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS51022; L27; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          46..104
FT                   /note="L27"
FT                   /evidence="ECO:0000259|PROSITE:PS51022"
FT   DOMAIN          126..205
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          211..279
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          336..523
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          98..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   538 AA;  59898 MW;  763938F62F7696B1 CRC64;
     MLGVGFKGLE ARGGVLFGIP GLLGLTGLTC TAFTPQAHER LEETKLEAVR DNNLELVQEI
     LRDLAQLAEQ SSTAAELARI LQEPHFQSLL ETHDSVASKT YETPPPSPGL DPTFSNQPVP
     PDAVRMVGIR KTSGEHLGVT FRVEGGELVI ARILHGGMVA QQGLLHVGDI IKEVNGQPVG
     SDPRALQELL RSASGSVILK ILPSYQEPHL PRQVFVKCHF DYDPARDSLI PCKEAGLRFN
     AGDLLQIVNQ DDANWWQACH VEGGSAGLIP SQLLEEKRKA FVKRDLELTP TSGTLCGSLS
     GKKKKRMMYL TTKNAEFXRH ELLIYEEVAR MPPFRRKTLV LIGAQGVGRR SLKNKLILWD
     PDRYGTTVPY TSRRPKDSER EGQGYSFVSR GEMEADIRAG RYLEHGEYEG NLYGTRIDSI
     RGVVASGKVC VLDVNPQAVK VLRTAEFVPY VVFIEAPDFE TLRAMNRAAL ESGVSTKQLT
     EADLRRTVEE SSRIQRGYGH YFDLSLVNSN LERTFRELQA AMEKLRTEPQ WVPVSWVY
//