ID A0A1A6G2P8_NEOLE Unreviewed; 1572 AA.
AC A0A1A6G2P8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 13-SEP-2023, entry version 25.
DE RecName: Full=Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=A6R68_08401 {ECO:0000313|EMBL:OBS60471.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS60471.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS60471.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS60471.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS60471.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS60471.1}.
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DR EMBL; LZPO01107895; OBS60471.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6G2P8; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00136; PDZ; 2.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000092124}.
FT DOMAIN 1..230
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 271..392
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 421..496
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 503..578
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 777..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1572 AA; 175527 MW; 76E30440916B3E3A CRC64;
MVWVPRQLLA AVKARAICGP QLHTGDAFLQ RIRQNVADSV EKGLTEENVK ILFSNIEDIL
EVHKDFLAAL EYCLHPEPQS QHELGNVFLK FVSMGAGETG RWKDKFCVYE EYCSNHEKAL
RLLVELNKVP AVRAFLLSCM LLGGRKTTDI PLEGYLLSPI QRICKYPLLL KASMTHVISI
EVADGCGHLD SHPVKFKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET KRQMEKLEAL
EQLQSHIEGW EVCGEAGGPW AEGAGPPTCN ADHSLGTLLK ISAGNIQERA FFLFDNLLVY
CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS NGYTVTNGWK
IHNTAKNKWF VCMAKTAEEK QKWLDALIRE REQRESLKLG MERDAYVMIA EKGEKLYHMM
MSKKVNLIKD RRRKLSTVPK CFLGNEFVAW LLEIGEISKT EEGINLGQAL LENGIIHHVS
DKHQFKNEQV MYRFRYDDGT YKARSELEDI MDRDYHLKTY KSVVPGSKLV DWLLAQGDCQ
TREEAVALGV GLCNNGFMHH VLEKSEFKDE SQYFRFHADE EMEGTSSKNK PLRNDFKLVE
NILAKRLLIP PQEDDYGFDL EEKNKAVVVK SVQRGSLAEM AGLQVGRKIY SIXEDLVFLR
PXSEVETILN QSFCSRRPLR LLVATKAKET IKVPDHPEAL SFQIRGAAPP CVFAVGRGSE
AVAAGLCAGQ CILKVNGNSV ANDGALEVLE HFQAFRSHRE EALGLYQWVY HSHEDAQQAR
ASQGAPDEDP QEDDQPDSXL PLLSLGPQLS LHEDGAVVSL TLDNVHLEHG VVYEYVSTAG
AKCHVLERIV EPRGCFRLAA KFHNICDTKL ESISQRITCY QEFAVQLKSK VSPPFKQAPL
EPHPLCGLDF CPTNCHVNLM EVSYPKTTPS VGRSFSIRFG RKPSLIGLDP EQGHLNPMAY
TQXCITTMAA PSWKCSSAVD GDSQGQALND SSFGSASGGP SQQDRGLSFL LKQEDREIQD
ALLSTITEPT STALCDPPLA EETSSSPPVS EESEVDRIDH GGIKKVCFKV SEDEQEDSGH
DTMSYRDSYS ECNSNRDSVL SYTSVRSNSS YLGSDEMGSG DELPCDMRIP SDKQDKLHGC
LEHLFNQVDS IHALLKGPVM SRAFEETRHF PMEHSWQEFK QKEECTVRGR NLIQISXQED
PWNLPNSIRT LVDNIQRYVE DGKNQLLLAL LKCTDTELQL RRDAVFCQAL VAAVCTFSEQ
LLAALDYRYN NNGEYEESSR DASRKWLEQV AATGVLLHWQ SLLTPATVVS GRGGGQHGRY
TITGSLSSCL SRGSCDTNVF YHIEGSRQAL KVVFYLDGFH FSRLPSRLEG GASLRLHTVL
FTKALENVEG PPSPGSQAAE DLQQEINAQS LEKVQQYYRK LRAFYLERSN LPTDAGTTAV
KIDQLIRPIN ALDELYRLMK SFVHPKAGTA GSLGAGLIPI SSELCYRLGA CQITMCGTGM
QRSTLSVSLE QAAILARSHG LLPKCVMQAT DIMRKQGPRV EILAKNLRIK DPMPQGAPRL
YRLCQPPVDG DL
//