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Database: UniProt
Entry: A0A1A6G2P8_NEOLE
LinkDB: A0A1A6G2P8_NEOLE
Original site: A0A1A6G2P8_NEOLE 
ID   A0A1A6G2P8_NEOLE        Unreviewed;      1572 AA.
AC   A0A1A6G2P8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   13-SEP-2023, entry version 25.
DE   RecName: Full=Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=A6R68_08401 {ECO:0000313|EMBL:OBS60471.1};
OS   Neotoma lepida (Desert woodrat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Neotominae; Neotoma.
OX   NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS60471.1, ECO:0000313|Proteomes:UP000092124};
RN   [1] {ECO:0000313|EMBL:OBS60471.1, ECO:0000313|Proteomes:UP000092124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=417 {ECO:0000313|EMBL:OBS60471.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:OBS60471.1};
RA   Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT   "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT   lepida.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBS60471.1}.
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DR   EMBL; LZPO01107895; OBS60471.1; -; Genomic_DNA.
DR   STRING; 56216.A0A1A6G2P8; -.
DR   Proteomes; UP000092124; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00136; PDZ; 2.
DR   CDD; cd01224; PH_Collybistin_ASEF; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR   Pfam; PF00610; DEP; 2.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00049; DEP; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS50186; DEP; 2.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000092124}.
FT   DOMAIN          1..230
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          271..392
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          421..496
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          503..578
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   REGION          777..804
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          979..1011
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1027..1054
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        979..1008
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1027..1051
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1572 AA;  175527 MW;  76E30440916B3E3A CRC64;
     MVWVPRQLLA AVKARAICGP QLHTGDAFLQ RIRQNVADSV EKGLTEENVK ILFSNIEDIL
     EVHKDFLAAL EYCLHPEPQS QHELGNVFLK FVSMGAGETG RWKDKFCVYE EYCSNHEKAL
     RLLVELNKVP AVRAFLLSCM LLGGRKTTDI PLEGYLLSPI QRICKYPLLL KASMTHVISI
     EVADGCGHLD SHPVKFKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET KRQMEKLEAL
     EQLQSHIEGW EVCGEAGGPW AEGAGPPTCN ADHSLGTLLK ISAGNIQERA FFLFDNLLVY
     CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS NGYTVTNGWK
     IHNTAKNKWF VCMAKTAEEK QKWLDALIRE REQRESLKLG MERDAYVMIA EKGEKLYHMM
     MSKKVNLIKD RRRKLSTVPK CFLGNEFVAW LLEIGEISKT EEGINLGQAL LENGIIHHVS
     DKHQFKNEQV MYRFRYDDGT YKARSELEDI MDRDYHLKTY KSVVPGSKLV DWLLAQGDCQ
     TREEAVALGV GLCNNGFMHH VLEKSEFKDE SQYFRFHADE EMEGTSSKNK PLRNDFKLVE
     NILAKRLLIP PQEDDYGFDL EEKNKAVVVK SVQRGSLAEM AGLQVGRKIY SIXEDLVFLR
     PXSEVETILN QSFCSRRPLR LLVATKAKET IKVPDHPEAL SFQIRGAAPP CVFAVGRGSE
     AVAAGLCAGQ CILKVNGNSV ANDGALEVLE HFQAFRSHRE EALGLYQWVY HSHEDAQQAR
     ASQGAPDEDP QEDDQPDSXL PLLSLGPQLS LHEDGAVVSL TLDNVHLEHG VVYEYVSTAG
     AKCHVLERIV EPRGCFRLAA KFHNICDTKL ESISQRITCY QEFAVQLKSK VSPPFKQAPL
     EPHPLCGLDF CPTNCHVNLM EVSYPKTTPS VGRSFSIRFG RKPSLIGLDP EQGHLNPMAY
     TQXCITTMAA PSWKCSSAVD GDSQGQALND SSFGSASGGP SQQDRGLSFL LKQEDREIQD
     ALLSTITEPT STALCDPPLA EETSSSPPVS EESEVDRIDH GGIKKVCFKV SEDEQEDSGH
     DTMSYRDSYS ECNSNRDSVL SYTSVRSNSS YLGSDEMGSG DELPCDMRIP SDKQDKLHGC
     LEHLFNQVDS IHALLKGPVM SRAFEETRHF PMEHSWQEFK QKEECTVRGR NLIQISXQED
     PWNLPNSIRT LVDNIQRYVE DGKNQLLLAL LKCTDTELQL RRDAVFCQAL VAAVCTFSEQ
     LLAALDYRYN NNGEYEESSR DASRKWLEQV AATGVLLHWQ SLLTPATVVS GRGGGQHGRY
     TITGSLSSCL SRGSCDTNVF YHIEGSRQAL KVVFYLDGFH FSRLPSRLEG GASLRLHTVL
     FTKALENVEG PPSPGSQAAE DLQQEINAQS LEKVQQYYRK LRAFYLERSN LPTDAGTTAV
     KIDQLIRPIN ALDELYRLMK SFVHPKAGTA GSLGAGLIPI SSELCYRLGA CQITMCGTGM
     QRSTLSVSLE QAAILARSHG LLPKCVMQAT DIMRKQGPRV EILAKNLRIK DPMPQGAPRL
     YRLCQPPVDG DL
//
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