ID A0A1A6GCF7_NEOLE Unreviewed; 651 AA.
AC A0A1A6GCF7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Phorbol-ester/DAG-type domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=A6R68_07562 {ECO:0000313|EMBL:OBS63898.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS63898.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS63898.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS63898.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS63898.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS63898.1}.
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DR EMBL; LZPO01097759; OBS63898.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A6GCF7; -.
DR STRING; 56216.A0A1A6GCF7; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd20860; C1_RASGRP1; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF174; RAS GUANYL-RELEASING PROTEIN 1; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 102..333
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 428..478
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT NON_TER 651
FT /evidence="ECO:0000313|EMBL:OBS63898.1"
SQ SEQUENCE 651 AA; 74548 MW; E0E4D36753C071DA CRC64;
MQMETCVEDA LEKNSPGICL KICYFVRYWI TEFWIMFKMD ASLTSTMEEF QDLVKANGEE
SHCRLIDTTQ INSRDWSRKL TQRIKSNTSK KRKVSLLFDH LEPEELSEHL TYLEFKSFRR
ISFSDYQNYL VNSCVKENPT MERSIALCNG ISQWVQLMVL SRPTPQLRAE VFIKFIHVAQ
KLHQLQNFNT LMAVIGGLCH SSISRLKETS SHVPHEINKV LGEMTELLSS CRNYDNYRRA
YGECTHFKIP ILGVHLKDLI SLYEAMPDYL EDGKVNVQKL LALYNHINEL VQLQEVAPPL
DANKDLVHLL TLSLDLYYTE DEIYELSYAR EPRNHRAPPL TPSKPPVVVD WASGVSPKPD
PKTISKHVQR MVDEAAIRRT KEKVSSKGWK PLFPYSPPYL EGLISRDEIT AYFMRASSIY
SKLGLGFPHN FQETTYLKPT FCDNCAGFLW GVIKQGYRCK DCGMNCHKQC KDLVVFECKK
RIKSPAVSTE NISSVVPMSN LCPLGTKDLL HGKQALETFA VGKAPEEGSF IFQNGEGVDH
SEESKDRTIM LLGVSSQKIS VRLKRTIAHK TTQTESFPWV GGEMPAGHFV LSSPRKPPQD
ALFVLPSPPS PCPSPVLFRK RAFVKWENKE SLIKPKQELH LRLRTYQELE Q
//
