ID A0A1A6GCP9_NEOLE Unreviewed; 636 AA.
AC A0A1A6GCP9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Cationic amino acid transporter C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=A6R68_07445 {ECO:0000313|EMBL:OBS64016.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS64016.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS64016.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS64016.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS64016.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS64016.1}.
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DR EMBL; LZPO01097482; OBS64016.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A6GCP9; -.
DR STRING; 56216.A0A1A6GCP9; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003333; P:amino acid transmembrane transport; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR029485; CAT_C.
DR PANTHER; PTHR43243:SF94; CATIONIC AMINO ACID TRANSPORTER 2; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR PIRSF; PIRSF006060; AA_transporter; 3.
PE 4: Predicted;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022970}.
FT TRANSMEM 39..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..409
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 534..584
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
SQ SEQUENCE 636 AA; 69781 MW; CD3E604068836BC0 CRC64;
MIPCRAVLTF ARCLIRRKIV TLDSLEDSKL CRCLTTMDLI ALGVGSTLGA GVYVLAGEVA
KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI
LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF KTYFKMNYTG LAEYPDFFAV CLILLLAGKE
TNQMLFPVMN HTNGPRESRE PPSENGTSIY GAGGFMPYGF TGTLAGAATC FYAFVGFDCI
ATTGEEVRNP QKAIPIGIVT SLLVCFMAYF GVSAALTLMM PYYLLDEKSP LPVAFEYVGW
GPAKYVVAAG SLCALSTSLL GSMFPLPRIL FAMARDGLLF RFLARVSKRQ SPVAATLTAG
VISEAFGFTF LICFPIAVMA FLFDLKALVD MMSIGTLMAY SLVAACVLIL RYQPGLCYEQ
PKYTPEKEIL ESCTSATSKS ESQVTMIQGQ SFSLRTLFNP SALPTRQSAS LVSFLVGFLA
FLILAMSILT TYGVQAIARL EAWSVALLIL FLVLCTAVIL TIWRQPQNQQ KVAFMVPFLP
FLPAFSILVN IYLMVQLSAD TWVRFSIWMV LGFLIYFAYG IRHSLEGNPR DEEDDEDVYS
DNINAATEEK STMQANDHHQ RSLSLPFIFH EKTSEC
//
