ID A0A1A6GGQ3_NEOLE Unreviewed; 1290 AA.
AC A0A1A6GGQ3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=A6R68_06069 {ECO:0000313|EMBL:OBS65406.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS65406.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS65406.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS65406.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS65406.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS65406.1}.
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DR EMBL; LZPO01096788; OBS65406.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6GGQ3; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17902; ArfGap_ARAP3; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd09490; SAM_Arap1_2_3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 4.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..58
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 277..369
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 384..473
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 470..601
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 989..1091
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 57..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1172..1290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OBS65406.1"
SQ SEQUENCE 1290 AA; 141248 MW; FA527BC387C26461 CRC64;
DLDIAVWLAA VHLEQYADTF RRHGLATAGA AQHLSHEELR HLGISATGHR KRILRLLQEG
SEGSLDSQVD STMEPSPSPA PDGQPPKPVP KPRTVFGLSG PATAQRPGLS PTFWDPEVSR
DSGSSQRSPP LLPSSTEQPS GLNTMEMMPN AIYFGLDLRG GAQAAQDTTP DGSQATAPTP
ALRPTKGTVH IMDPGCLYYG VQPVGVPGAL DRRDGRGVCQ DRAEHRQDLE TREDAGYASL
ELPGDSILSL PTQDAEETSD DLISPYASFS SAADRPMPLL SGWLDKLSPQ GNYVFQRRFV
QFNGRSLMYF GSDKDPFPKG VIPLTAIEMT RSSKDNKFQV ITGQRVFVFR TESEAQRDIW
CSTLQSCLKE QRLLGHPRPP HPPRPLRTGM LELRGHKAKV FAALIPGELA LYKSEQAFSL
GIGICFIELQ GCSVRETKNR SFDLLTPHRC FSFTAESGGA RQSWAAALQE AVTETLSDYE
VAEKVWSNRA NRHCADCGAS RPDWAAVNLG VVICKQCAGQ HRALGSGISK VQSLKLDTSV
WSNEIVQLFI VLGNDRANSF WAGALPPGEG LHPDSAPGPR GEFISRKYKL GLFRKPHPQH
PDHSQLLQAL CAAMAGPNLL KNMTQLLCVE ASEGEEPWSP SALNGSLLSL HPSDSSPGVY
NEVVVPATYR SFLYCGPISS KAGAPPLRRG RDAPPRLWCV LGAALEMFAS ESSPEPLSLL
QPQDVVCLGV SPPPADPGDL DRFPFSFELI LTGGRIQHFA TDGADSLEAW ITAVGKLPQK
NQRLEKYKDV IGCLPRVNRR TLATLIGHLY RSMCTRNLAL LFAPSVFQTD GRGEHEVRVL
QELIDGYISV FDIDSDQAAQ IDLEVSLITT WKDVQLSQAG DLIMEVYIEQ QLPDNCVTLK
VSPTLTAEEL TNQVLEMRGT VSGTDLEATA PQRKGXRAGP SMVPASRALL SLSAPEKSLH
GARWLPFHRP LSQEPPPSIA LLCPGVRRES PRVGLLRCRE EPPRLLGSRF QERFFLVRGR
CLLLLKEKKS SKPEREWSLE GAKVYLGIRK KLKPPTPWGF TLILDKMHLC LSCTHEDEMW
DWTTSILKAQ HDDQQSVVLR RRSSSDLARQ KFGTMPLLPI RGDDSGATLL SANQTLGSVE
EQEELGEPVY EEPVYEEVGA FPELTKDTTD FSSTWEWTAK PETPLASHRS FDQTPLSKAX
MSGQEERIPD SSSGPPSKSS PQARGSLEEQ LLQELNNLIL RKGEPATCPE SPSQPTSPQT
PSLASLPTQA PGLPTQTPCT STPPSSQPLT
//
