ID A0A1A6GHV1_NEOLE Unreviewed; 217 AA.
AC A0A1A6GHV1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=glutaminyl-peptide cyclotransferase {ECO:0000256|ARBA:ARBA00012012};
DE EC=2.3.2.5 {ECO:0000256|ARBA:ARBA00012012};
DE Flags: Fragment;
GN ORFNames=A6R68_06621 {ECO:0000313|EMBL:OBS64872.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS64872.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS64872.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS64872.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS64872.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-
CC [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736,
CC Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722,
CC ChEBI:CHEBI:87215; EC=2.3.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000001};
CC -!- SIMILARITY: Belongs to the glutaminyl-peptide cyclotransferase family.
CC {ECO:0000256|ARBA:ARBA00006014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS64872.1}.
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DR EMBL; LZPO01097126; OBS64872.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6GHV1; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0016603; F:glutaminyl-peptide cyclotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.630.10; Zn peptidases; 2.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR040234; QC/QCL.
DR PANTHER; PTHR12283; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR PANTHER; PTHR12283:SF3; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-LIKE PROTEIN; 1.
DR Pfam; PF04389; Peptidase_M28; 2.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..158
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 167..209
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OBS64872.1"
SQ SEQUENCE 217 AA; 23639 MW; 9594C42DFA4D3CFB CRC64;
FLEATLXSLS AGWHVELDPF TASTPLGPLD FGNVVATLDP GAPRHLTFAC HYDSKFFPPG
SPPFVGATDS AVPCALLLEL VQAFDAAPVT LQLLFLDGEE ALKEWGPXDS LYGSRHLAQI
MESIPHSPGP TRIQAIELFV LLDLLGAPSP IFFSHFPRTA RWFQRLRSIG VPVLHLIATP
FPAVWHTPAD TEANLHPPTV HNLSRILAVF LAEYLGL
//
