ID A0A1A6GKZ9_NEOLE Unreviewed; 410 AA.
AC A0A1A6GKZ9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Prestin {ECO:0000256|ARBA:ARBA00040148};
DE AltName: Full=Solute carrier family 26 member 5 {ECO:0000256|ARBA:ARBA00042390};
DE Flags: Fragment;
GN ORFNames=A6R68_05447 {ECO:0000313|EMBL:OBS66012.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS66012.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS66012.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS66012.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS66012.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2
CC hydrogencarbonate(out); Xref=Rhea:RHEA:72207, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00036219};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS66012.1}.
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DR EMBL; LZPO01087704; OBS66012.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A6GKZ9; -.
DR STRING; 56216.A0A1A6GKZ9; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF32; PRESTIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 4: Predicted;
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..342
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 382..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OBS66012.1"
FT NON_TER 410
FT /evidence="ECO:0000313|EMBL:OBS66012.1"
SQ SEQUENCE 410 AA; 44970 MW; 938E48D2D7247BD3 CRC64;
LLPPANPDTS LFHLVYVDAI AIAIVGFSVT ISMAKTLANK HGYQVDGNQE LIALGICNSI
GSLFQTFSIS CSLSRSLVQE GTGGKTQLAG CLASLMILLV ILATGFLFES LPQAVLSAIV
IVNLKGMFMQ FSDLPFFWRT SKIELTIWLT TFVSSLFLGL DYGLITAVII ALLTVIYRTQ
SPSYKVLGQL PDTDVYIDID AYEEVKEIPG IKIFQINAPI YYANSDLYSN ALKRKTGVNP
ALIMGARRKA MRKYAKEVGN ANVANATVVK VDAEVDGEDA TKPEEEDDEV KYPPIVIKTT
FPEEMQRFMP QGENVHTVIL DFTQVNFIDS VGVKTLAGIV KEYGDVAQVV NDLTRNRFFE
NPALKELLFH SIHDAVLGSQ VREAMAERET SAPTPQDDME PNATPTTPEA
//