ID A0A1A6GLB3_NEOLE Unreviewed; 1284 AA.
AC A0A1A6GLB3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Histone-lysine N-methyltransferase NSD3 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=A6R68_04380 {ECO:0000313|EMBL:OBS67073.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS67073.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS67073.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS67073.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS67073.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS67073.1}.
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DR EMBL; LZPO01087155; OBS67073.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6GLB3; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR CDD; cd15658; PHD4_NSD3; 1.
DR CDD; cd15661; PHD5_NSD3; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR041306; C5HCH.
DR InterPro; IPR047458; PHD4_NSD3.
DR InterPro; IPR047527; PHD5_NSD3.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22884:SF473; HISTONE-LYSINE N-METHYLTRANSFERASE NSD3; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF17982; C5HCH; 1.
DR Pfam; PF00855; PWWP; 2.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00249; PHD; 3.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00293; PWWP; 2.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50812; PWWP; 2.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 220..277
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 837..881
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 952..1002
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1004..1110
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1117..1133
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 1168..1215
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 110..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 893..920
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 113..131
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1284
FT /evidence="ECO:0000313|EMBL:OBS67073.1"
SQ SEQUENCE 1284 AA; 143565 MW; A27ACFF30682494A CRC64;
MGNTIQQPPQ LIDSANIRQE DAFDNNSDIV EDGGQTPFEA TLQQGFQYPP TTEDLPPLTN
GYPPSISLYE TQTKYPPYNQ YPNGSANGFG AVRNFSPTDY YHSEIPNTRP HEILEKPSPP
QPPPPPSVPQ TVIPKKTGSP EIKLKITKTI QNGRELFESS LCGDLLNEVQ ASEHTKPNER
VDTAPEKPRE EPVLKEAEPV QPILSSVPTT EASTGVKFQV GDLVWSKVGT YPWWPCMVSS
DPQLEVHTKI NTRGAREYHV QFFSNQPERA WVHEKRIRKP RPQRERAQWD IGIAHAEKAL
KMTREERVEQ YTFIYIDKQP EEASSQAKKN VTSKTEVKKP RRPRSVLNSQ PEQTNAGEVA
SSQPSTDHRR QSQRRHTSVE EEEPPPVKIA WKTAAARKSL PASITMHKGS LDLQKCNMSP
VVKIEQVFAL QNATGDGKFI DQFVYSTKGI GNKTEISVRG QDRLIISSPS QRNEKPTQNT
SSPEATSGSA GPVEKKQQRR SIRTRSESEK STEVVPKKKT KKEQVETAPQ ASLKTGLQKG
ASEISDSCKP LKKRSRASTD VDMANSAYRD TSDSDSRGLS DLQVGFGKEG DSPLAAADAS
DSQSVDSSLS RRGIGMSKKD TVCQDVKRCS VSVCGKFYHE ACVRKFPTAI FESKGFRCPQ
HCCSSCSVEK DIYKASKGRM MRCLRCPVAY HFGDACVAAG SVSVSSHTLI CSNHSKRSSH
SAAVNVGFCF VCARGLIVQD HSDPMFSSYA YKSHYLLNES NRAELMKLPM IPSSSASKKK
CEKATKTVCL FQGGKLLCCE SCPASFHPEC LNIDMPEGCW NCNDCKAGKK LHYKQIICSP
RSVPLNIQGL RHDLGDFPVF FFGSHDYYWV HQGRVFPYVE GDKSFAEGQT SINKTFKKAL
EEAAKRFQEL KAQRESKEAL EIEKTSRKPP PYKHIKANKV IGKVPIQVAD LSEIPRCNCK
PADENPCGLE SECLNRMSQY ECHPQVCPAG DRCQNQCFTK RLYPDAEIIK TERRGWGLRT
KRSIKKGEFV NEYVGELIDE EECRLRIKRA HENSDRIIDA GPKGNYSRFM NHSCNPNCET
QKWTVNGDVR VGLFALCDIP AGMELTFNYN LDCLGNGRTV CHCGADNCSG FLGVRPKSAC
ASTGDEKTKN AKVKKRRKMK TEPKQIHEDY CFQCGDGGEL VMCDKKDCPK AYHLLCLNLT
QPPYGKWECP WHQCDECNNA AVSFCEFCPH SFCKDHEKGA LVPSALEGRL CCSDHNPESP
VAPEYWSKIR CKWESQDPGE EVKE
//
