ID   A0A1A6GU61_NEOLE        Unreviewed;      1080 AA.
AC   A0A1A6GU61;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   13-SEP-2023, entry version 17.
DE   RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=A6R68_02587 {ECO:0000313|EMBL:OBS68872.1};
OS   Neotoma lepida (Desert woodrat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Neotominae; Neotoma.
OX   NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS68872.1, ECO:0000313|Proteomes:UP000092124};
RN   [1] {ECO:0000313|EMBL:OBS68872.1, ECO:0000313|Proteomes:UP000092124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=417 {ECO:0000313|EMBL:OBS68872.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:OBS68872.1};
RA   Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT   "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT   lepida.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBS68872.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LZPO01075859; OBS68872.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A6GU61; -.
DR   STRING; 56216.A0A1A6GU61; -.
DR   Proteomes; UP000092124; Unassembled WGS sequence.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR46299:SF1; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B1; 1.
DR   PANTHER; PTHR46299; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B2-RELATED; 1.
DR   Pfam; PF13757; VIT_2; 1.
DR   Pfam; PF13768; VWA_3; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000092124}.
FT   DOMAIN          1..96
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          281..449
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          511..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..633
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          831..859
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          960..988
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        511..530
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..621
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1080 AA;  119242 MW;  E85D966ECE8335BC CRC64;
     MKYQQLKRRG LFVYPMDEYT TVVGFEAVIA DRVVTIQIKD KAKLDKSHLD IQSATVTGLM
     TAPSGVRVDL ERILFVVNLG TIAPMENVTV FISTSSELPT LPSGAVRVVL PAICAPTVPQ
     FCSHRYGSSS QQAQGKDPHC FGIQTMDSWN GLCLATLLDT EVTNPMEYEF NFQLEIRGPY
     LLAGVESPTH EVRADAAPSA HSAKSIIITL ANKHTFDRPV EILLHPSEPH MPHVLVEKGD
     MTLGEFDQHL KGKADFIRGT KKDGSAERKS VQPNLRKTHG EFIFLVDRSS SVSKTSVQCV
     KEAMLVALKS LRLDCLFNIV GFGSTFKTVF ASSQIYNEEN LAIACNCIQR IRADMGSTNI
     LSPLKWIFRQ PVHQGHPRLL FLITDGAVSN TGKVLELVRN HASSTRCYSF GIGPSVCYRL
     VKGLASVSKG SAEFLTEGER LQPKMIKSLK KAMAPMLSDV TVEWVFPETT EVLISPVSTS
     SLFPGDRLMG YGIVIKGESL DVFRRRRAYS TNQISSQKGP RATTASDPTG TARRYPLRKA
     KVQDLANQSS SGSQRLQIDL QPLLNSGHDL SQGPRLHGPG ARRPSLLPQG CQSLLFSGQE
     PQAWSPMQEL DRGSSPKSAP DSRSSEDLEL PLHPSTFETE ISSDWEPMAE SEEQVSPCRP
     ATPGPVLGKA LVKGLCDNQC LQWEVSFELE PPALQRGNAQ NADMWSETFH HLAARAIIRD
     FEQLAEREDE IELGSNRRYQ VNAVHTSKAC NVISKYTAFV PVDINKRRYL PTVVKYPNSG
     AMQQMVSFRN LTRQWKRASA NVGRSQTMLR EQASAAGDNK FQTLALEESP TSTISKLLSP
     SREKHTGAEG PPHNLSTSAP SSIKASEALF VTKLNLHKPR LLTQAAKGFL SKSLAKAPEP
     IPSIQSFDYI PLVSLQLASG AFLLDQAFCE AIQIPMEKLK WTSPFMCLRM SLVTHRHESK
     SQSPQHGIGL SSPCPPCEDT SLESQAESSS GLDPSVLLEC TGKLWATAVA LAWLEHSSAS
     YFIEWELVAA KASLWLEQQK VPEGRTLSTL KATARQLFVL LRHWDENLEF NMLCYNPNYV
//