ID A0A1A6GWN0_NEOLE Unreviewed; 175 AA.
AC A0A1A6GWN0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 22-FEB-2023, entry version 18.
DE RecName: Full=Gremlin {ECO:0000256|PIRNR:PIRNR037254};
GN ORFNames=A6R68_01434 {ECO:0000313|EMBL:OBS70025.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS70025.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS70025.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS70025.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS70025.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR037254}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872,
CC ECO:0000256|PIRNR:PIRNR037254}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS70025.1}.
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DR EMBL; LZPO01066480; OBS70025.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A6GWN0; -.
DR STRING; 56216.A0A1A6GWN0; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR InterPro; IPR017159; Gremlin-1/2.
DR PANTHER; PTHR15283; GREMLIN 1; 1.
DR PANTHER; PTHR15283:SF2; GREMLIN-2; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF037254; Gremlin_precursor; 1.
DR SMART; SM00041; CT; 1.
DR PROSITE; PS01225; CTCK_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR037254};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR037254-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037254};
KW Signal {ECO:0000256|PIRNR:PIRNR037254}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT CHAIN 29..175
FT /note="Gremlin"
FT /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT /id="PRO_5008452871"
FT DOMAIN 80..170
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 80..130
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1,
FT ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 94..144
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 104..162
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 108..164
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
SQ SEQUENCE 175 AA; 20056 MW; F54CC7E49721670D CRC64;
MYGTKQAMFW KLSLTLLLVA VLVKVAEGRK NRPAGAIPSP YKDGSSNNSE RWHHQIKEVL
ASSQEALVVT ERKYLKSDWC KTQPLRQTVS EEGCRSRTIL NRFCYGQCNS FYIPRHVKKE
EDSFQSCAFC KPQRVTSVIV ELDCPGLDPP FRIKKIQKVK HCRCMSVNLS DSDKQ
//
