ID   A0A1A6H1J9_NEOLE        Unreviewed;       806 AA.
AC   A0A1A6H1J9;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=TRPM SLOG domain-containing protein {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=A6R68_13170 {ECO:0000313|EMBL:OBS72251.1};
OS   Neotoma lepida (Desert woodrat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Neotominae; Neotoma.
OX   NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS72251.1, ECO:0000313|Proteomes:UP000092124};
RN   [1] {ECO:0000313|EMBL:OBS72251.1, ECO:0000313|Proteomes:UP000092124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=417 {ECO:0000313|EMBL:OBS72251.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:OBS72251.1};
RA   Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT   "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT   lepida.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBS72251.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LZPO01055148; OBS72251.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A6H1J9; -.
DR   STRING; 56216.A0A1A6H1J9; -.
DR   Proteomes; UP000092124; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR041491; TRPM_SLOG.
DR   PANTHER; PTHR13800:SF9; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8; 1.
DR   PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF18139; LSDAT_euk; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT   TRANSMEM        505..524
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        536..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        605..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        637..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        675..696
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        777..797
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..187
FT                   /note="TRPM SLOG"
FT                   /evidence="ECO:0000259|Pfam:PF18139"
FT   DOMAIN          590..787
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   NON_TER         806
FT                   /evidence="ECO:0000313|EMBL:OBS72251.1"
SQ   SEQUENCE   806 AA;  92639 MW;  0826399EF781B8D6 CRC64;
     MKYIGEVVRD NTISRNSEEN IVAIGIAAWG MVSNRDTLIR NCNDEGYFSA QYIMDDFKRD
     PLYILDNNHT HLLLVDNGCH GHPTVEAKLR NQLEKYISER TSQDSNYGGK IPIVCFAQGG
     GRETLKAINT SIKSKIPCVV VEGSGQIADV IASLVEEEDV LTSSMVKEKL VRFLPRTVSR
     LPEEEIESWI KWLREILECP HLLTVIKMEE AGDEIVSNAI SYALYKAFST NEQDKDNWNG
     QLKLLLEWNQ LDLASDEIFT NDRRWESADL QEVMFTALIK DRPKFVRLFL ENGLNLKKFL
     TNDVLTELFS THFSTLVYRN LQIAKNSYND ALLTFVWKLV ANFRRSFWKE DRSSREDLDV
     ELHDASLTTR HPLQALFIWA ILQNKKELSK VIWEQTKGCT LAALGASKLL KTLAKVKNDI
     NAAGESEELA NEYETRAVEL FTECYSNDED LAEQLLVYSC EAWGGSNCLE LAVEATDQHF
     IAQPGVQNFL SKQWYGEISR DTKNWKIILC LFVIPLVGCG LVSFRKKPID KHKKLLWYYV
     AFFTSPFVVF SWNVVFYIAF LLLFAYVLLM DFHSIFMTDV QAAHSLSAPF LLQWYMSGVN
     YFTDLWNVMD TLGIFYFIAG IVFRLHSSNT SSLYSGRVIF CLDYIIFILR LIHIFTVSRN
     LGPKIIMLQR MLIDVFFFLF LFAVWMVAFG VARQGILRQN EQRWRWIFRS VIYEPYLAMF
     GQVPSDVDGT TYDFSHCTFS GNESKPLCVE LDENSLPRFP EWITIPLVCV YMLSTNILLV
     NLLVAMFGYV CVTIHGLPLR ALPMPG
//