ID A0A1A6H1R0_NEOLE Unreviewed; 699 AA.
AC A0A1A6H1R0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=TRMT1-like protein {ECO:0000256|ARBA:ARBA00015939};
GN ORFNames=A6R68_13222 {ECO:0000313|EMBL:OBS72204.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS72204.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS72204.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS72204.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS72204.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in motor coordination and exploratory
CC behavior. {ECO:0000256|ARBA:ARBA00003652}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Trm1 family. {ECO:0000256|PROSITE-ProRule:PRU00958}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS72204.1}.
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DR EMBL; LZPO01055158; OBS72204.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6H1R0; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.56.70; N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002905; Trm1.
DR InterPro; IPR042296; tRNA_met_Trm1_C.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10631; N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10631:SF1; TRMT1-LIKE PROTEIN; 1.
DR Pfam; PF02005; TRM; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51626; SAM_MT_TRM1; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Behavior {ECO:0000256|ARBA:ARBA00022610};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00958};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00958};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; tRNA processing {ECO:0000256|PROSITE-ProRule:PRU00958};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 177..197
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 77828 MW; F4281F7DD9720925 CRC64;
MENMAEEELP PQEEEAQVRV PTPAPDSAPV PAPAADSALD SAPTPDSAPA PALAPAPAPA
LSPSLASVPE EAESKRHISI QRRLADLEKL AFVTEGDIDA ASSLNSENSH TCPLCPKEKF
RAYSSQKLRR HLQNLHWKIS VEFEGYRMCI CHLACRPVKP TIVGEQLSSK LGAHYHCIIC
SATITRRTDM LGHVKRHVNK GETKSRYIAA STAKSSNEIL KEADTDIQVC PNYSIPQKTD
SYFNPKMKLN RPVERIMGLQ WAKHLGNAVK VTINDXNENS VTLIQKNCHL NKLKVVVDSE
EKEEGDALEE DGTLGDIQVT RMDANVLMHL RSFDFIHLDP FGTSVNYLDS AFRNVRNLGI
VSVTSTDISS LYAKAQHVAR RHYGCNIVRT EYYKELAARI VVAAVARAAA RCNKGIEVLF
AVALEHFVLV VVRVLRGPTS ADETAKKIQY LIHCQWCEER IFQKDGNMVE ENPYRQLPCN
CHGSMPGKTA IELGPLWSSS LFNTGFLKRM LFESLHHGLD DIQPLIKTLI FESECTPQSQ
CSVHAPSNLN KQEENGVFIK TTDDTTVDIY SAQGKRKSSE MIINTVKKQK TDVSAAHPPF
YYNIHRHSIK GMNMPKLKKF LCCLSQAGFR VSRTHFDPMG IRTDAPLMQF KSILLKYSTP
TYTGGQSEGP MQSASEDTVA DRVEMSVNDK AEVSGCRRW
//
