ID   A0A1A6H371_NEOLE        Unreviewed;       987 AA.
AC   A0A1A6H371;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Insulin-degrading enzyme {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=A6R68_12387 {ECO:0000313|EMBL:OBS73043.1};
OS   Neotoma lepida (Desert woodrat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Neotominae; Neotoma.
OX   NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS73043.1, ECO:0000313|Proteomes:UP000092124};
RN   [1] {ECO:0000313|EMBL:OBS73043.1, ECO:0000313|Proteomes:UP000092124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=417 {ECO:0000313|EMBL:OBS73043.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:OBS73043.1};
RA   Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT   "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT   lepida.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBS73043.1}.
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DR   EMBL; LZPO01054714; OBS73043.1; -; Genomic_DNA.
DR   STRING; 56216.A0A1A6H371; -.
DR   Proteomes; UP000092124; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 5.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 5.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          33..171
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          197..375
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          381..471
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          548..667
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          681..857
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   NON_TER         987
FT                   /evidence="ECO:0000313|EMBL:OBS73043.1"
SQ   SEQUENCE   987 AA;  114055 MW;  3D3EA137CC2BF0EC CRC64;
     MNNPAIQRIE DQIVKSPEDK REYRGLELAN GIKVLLISDP TTDKSSAALD VHIGSLSDPP
     NIAGLSHFCE HMLFLGTKKY PKENEYSQFL SEHAGSSNAF TSGEHTNYYF DVSHEHLEGA
     LDRFAQFFLC PLFDASCKDR EVNAVDSEHE KNVMNDAWRL FQLEKATGNP KHPFSKFGTG
     NKYTLETRPN QEGIDVRQEL LKFHSTYYSS NLMAICVLGR ESLDDLTNLV VKLFSEVENK
     NVPLPEFPEH PFQEEHLKQL YKIVPIKDIR NLYVTFPIPD LQQYYKSNPG HYLGHLIGHE
     GPGSLLSELK SKGWVNTLVG GQKEGARGFM FFIINVDLTE EGLLHVEDII LHMFQYIQKL
     RAEGPQEWVF QECKDLNAVA FRFKDKERPR GYTSKIAGKL HYYPLNGVLT AEYLLEEFRP
     DLIDMVLDKL RPENVRVAIV SKSFEGKTDR TEQWYGTQYX QEAIPEEVIQ DTAMSKLWFK
     QDDKFFLPKA CLNFEFFSPF AYVDPLHCNM AYLYLELLKD SLNEYAYAAE LAGLSYDLQN
     TIYGIRYIYA DPLHCNMTYL FIRLLKDDLK EYTYAARLSG LSYAIASGMN AILLSVKGYN
     DKQPILLKKI TEKMATFEID KKRFEIIKEA YMRSLNNFRA EQPHQHAMYY LRLLMTEVAW
     TKDELKEALD GSKNLRTQYG HAFIPQLLSR LHIEALLHGN ITKQAALGIM QMVEDTLIEH
     AHTKPLLPSQ LVRYREVQLP DRGWFVYQQR NEVHNNCGIE IYYQTDMQST SENMFLELFC
     QIISEPCFNT LRTKEQLGYI VFSGPRRANG IQGLRFIIQS EKPPHYLESR VEAFLLTMEK
     AIEDMTEEAF QKHIQALAIR RLDKPKKLSA ECAKYWGEII SQQYNYDRDN IEVAYLKTLT
     KDDIIRFYKE MLAVDAPRRH KVSVHVLARE MDSCPVVGEF PSQNDINLSE APALPQPEVV
     QNMTEFKRGL PLFPLVKPHI NFMAAKL
//