ID A0A1A6H395_NEOLE Unreviewed; 1813 AA.
AC A0A1A6H395;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
GN ORFNames=A6R68_12361 {ECO:0000313|EMBL:OBS73068.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS73068.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS73068.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS73068.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS73068.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS73068.1}.
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DR EMBL; LZPO01054713; OBS73068.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6H395; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF9; PLEXIN-B2; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1813
FT /note="Sema domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008346054"
FT DOMAIN 8..464
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1813 AA; 202535 MW; AC2882AD81248D8F CRC64;
MALSLWALTF LGLVGLGASL RSRKPESFRS DTELNHLVVD EASGVVYVGA VNALFQLSAD
LHLQQRVATG PAKDNKKCTP PIEASQCHEA VLTDNVNQLL LLDPPGKRLV ECGSLFKGIC
ALRALSNISV RLFYEDGSGE KSFVASNDER VTTVGLVSST GPAGDRVLFV GKGNGPHDNG
IIVSTRLLDR AEGREAFEAY SDHTTFKAGY LSTNTQQFVT AFEDGLYVFF IFNQQDKHPA
RNRTLLARMC KDDPSYYSYV EMDLQCLDPS DPQGLAFGTC LAASVAGRVL YAVFSRDGRS
SGGPGAGLCV FPLDEVNAKM EANRNTCYTG TREASRDTFY KPFHGDIQCG GHVLGASESF
PCGSEHLPYP LGSRDGLVTT ALLYRGGLNL TAVTVTAENG HTVAFLGTSD GRILKVYLAP
DGTSAEYGSI PVDINKKIKQ DLALSGNLSS LYAMTQDKVF RLPVQECLSY LTCAQCRDSQ
DPYCGWCVVE GRCTRKAECS RAEEAGHWLW SRNKSCVAIT DASPQNMSRR TQGEVRLSVS
PLPTLTEEDE LLCLFGESPP HHAQIEGDTV ICNSPSSIPR TPPGQDHVAV SIQLLFQRGN
VFLTSHQYPF YDCREAMSLV ENLPCISCAS NRWMCQWNLL HHECQEASPS PEDGVIYAHM
EDNCPQFLDP SPLVIPMNHE TEVTFQGKNL DTVEVSSLSV GSDLLKFEAT VTMLEPEAFS
FKTPKLSHDG NETLPLHLYV KSSDKNIDSK LQVTLYNCSF GRSDCSLCLA ADPAYRCVWC
RGQXRCVYEA LCSNVTSECP PPVITRIQPE TGPLGGGIRV TIHGSNLGIT ADDVKKITVA
GQNCAFEPXW YSVSTRIVCA IEAAEMSFTG GIEVDINGKL GHSPPHVQFT YQQPQPLSVE
PRQGPQAGGT TLTINGTHLD TGSKEDVRVT LNDVPCEVTK FGAQLQCITG PQLAPGQVVL
EISYGGSRVP SSGVSFTYCE NPVLRAFEPL RSFVSGGRSI NVTGQGFSLI QKFAMVVIAE
PLRSWRRRRE AGSLEPMTVT GTEYVFYNDT KVVFLSPAVP EEPEAYNLTA LIQMDGHRAL
LRTEAGAFEY VADPTFENFT GGVKKQVNKL IHARGTNLNK AMTLEEAEAF VGAERCIMKT
LTETDLYCEP PEVQPPPKRR QKRDTTHNLP EFIVKFGSRE WVLGRVEYDT RVSDVPLSLI
LPLVMVPMVF IIAVSIYCYW RKSQQAEREY EKIKSQLEGL EESVRDRCKK EFTDLMIEME
DQTNDVHEAG IPTLDYKTYT DRVFFLPSKD GDKDVMITGK LDIPESRRPI VEQALYQFSN
LLNSKSFLIN FIHTLENQRE FSARAKVYFA SLLTVALHGK LEYYTDIMRT LFLELMEQYV
VAKNPKLMLR RSETVVERML SNWMSICLYQ YLKDSAGEPL YKLFKAIKHQ VEKGPVDAVQ
KKAKYTLNDT GLLGDDVEYA PLTVSVIVQD EGINAIPVKV LNCDTISQVK EKIIDQVYRT
QPCSCWPKPD SVVLEWRPGS TAQILSDLDL TSQREGRWKR INTLMHYNVR DGATLILSKV
GVSQQPEDSQ QDLPGERHAL LEEENRVWHL VRPTDEVDEG KSKRGSMKEK ERTKAITEIY
LTRLLSVKGT LQQFVDNFFQ SVLAPGHAVP PAVKYFFDFL DEQAEKHDIR DEDTIHIWKT
NSLPLRFWVN ILKNPHFIFD VHVHEVVDAS LSVIAQTFMD ACTRTEHKLS RDSPSNKLLY
AKEISTYKKM VEDYYKGIRQ MVQVSDQDMN THLAEISRAH TDSLNTLVAL HQLYQYTQKY
YDERLHPRHL EWV
//
