ID A0A1A6H4P4_NEOLE Unreviewed; 714 AA.
AC A0A1A6H4P4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=IRG-type G domain-containing protein {ECO:0000259|PROSITE:PS51716};
GN ORFNames=A6R68_15899 {ECO:0000313|EMBL:OBS73563.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS73563.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS73563.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS73563.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS73563.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. IRG family. {ECO:0000256|ARBA:ARBA00005429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS73563.1}.
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DR EMBL; LZPO01045356; OBS73563.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6H4P4; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR CDD; cd04104; p47_IIGP_like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR030385; G_IRG_dom.
DR InterPro; IPR007743; Immunity-related_GTPase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR32341:SF2; INTERFERON-GAMMA-INDUCIBLE GTPASE IFGGA2 PROTEIN-RELATED; 1.
DR PANTHER; PTHR32341; INTERFERON-INDUCIBLE GTPASE; 1.
DR Pfam; PF05049; IIGP; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51716; G_IRG; 2.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124}.
FT DOMAIN 67..249
FT /note="IRG-type G"
FT /evidence="ECO:0000259|PROSITE:PS51716"
FT DOMAIN 364..546
FT /note="IRG-type G"
FT /evidence="ECO:0000259|PROSITE:PS51716"
SQ SEQUENCE 714 AA; 81167 MW; EAD661B687C8C16F CRC64;
MGQLFSSSKD EHKVLASGFT EYFKKIKVEN TIIPQETIAS IESSLTKGNI QGANSSITNA
VKEIDSTPLN VAVTGESGAG KSAFINALRG VGHEDEDAAA IGVVETTMKR HPYKHPNIPN
VVFWDLPGIG SMNFSPKDFL EKVKFHEYDF FIIVSATRFK KNDIDLAKAV SMMKKDFYFV
RTKVDSDVKN EKEFKPRTFD REKVLQQIHD ICVKIFQENN IAEPPIFLIS NINLSDYDFP
VLMDKVVNAL PVHKRHSFML SLPNVTGAVI ERKRQFLKQR IWLEAFATDL LSIIPSLTLL
MDSDVESLKK SLNFYRTVFG VDDASLQSLA EDWQMSVDKL KAMMKSSNGA NSSITDAVKE
IDSTPLNVAV TGESGAGKSA FINALRGVGH EDEDAAEVGI VETTIKRHPY KHPNIPNVVF
WDLPGIGTKN FPPKDYLEKM KFHEYDFFII VSATRFXKND IDLAKAVSMM KKDFYFVRTK
VDSDVKNEKE FKPRTFDREK VLQQIHANCV KIFQENNIAE PPIFLISNIN LSDYDFPILM
DKMVNALPVH KRHNFMLSLP NVTGAAIERK RQFLKQRIWL EAFATDLLSI IPSLTLLMGS
DVENLKKSLN FYRTVFGVDD ASLQSLAEEW QMSVDQLKAK MKSPNVFETT KEEPIQERLS
RYYEEFCLAN GHLIDKNVYV KEIFYLKLYF LDMVTDDANA LLREICSRNN LVSD
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