ID A0A1A6H5T2_NEOLE Unreviewed; 661 AA.
AC A0A1A6H5T2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=HELP domain-containing protein {ECO:0000259|Pfam:PF03451};
DE Flags: Fragment;
GN ORFNames=A6R68_12462 {ECO:0000313|EMBL:OBS72967.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS72967.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS72967.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS72967.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS72967.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS72967.1}.
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DR EMBL; LZPO01055068; OBS72967.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A6H5T2; -.
DR STRING; 56216.A0A1A6H5T2; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF11; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT TRANSMEM 46..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..66
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 275..307
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 358..390
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 541..575
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 616..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 661
FT /evidence="ECO:0000313|EMBL:OBS72967.1"
SQ SEQUENCE 661 AA; 74018 MW; 98DF31FFCE063282 CRC64;
MFMRGRPITM FIPSDVDNYD DIRTELPPEK LKLEYGYRGK DCRANVYLLP TGEIVYFIAS
VVVLFNYEER TQRHYLGHTD CVKCLAIHPD KIRIATGQIA GVDKDGRALQ PHVRVWDSVS
LSTLHVIGLG TFERGVGCLD FSKADSGVHL CVIDDSNEHM LTVWDWQRKS KVAEIKTTNE
VVLAVEFHPT DANTIITCGK SHIFFWTWSG NSLTRKQGIF GKYEKPKFVQ CLAFLGNGDV
LTGDSGGIML IWSKTTVEPP PGKGPKGVYQ INRQIKAHDG SVFTLCQMRN GMLLTGGGKD
RKIILWDHDL NPEREIEVPD QYGTIRAVAE GKAEQFLVGT SRNFILRGTF NDGFQIEVQG
HTDELWGLAT HPFKDLLLTC AQDRQVCMWN SVEHRLEWFV LDAETRDLVS IHTDGNEQLS
VMRYSVDGTL LAVGSHDNFI YLYTVSENAR KYSRYGKCTT WVSPICSCFC CHPPARRLDM
NLETALPYLQ LGVWPEGSDG TDINALVRSH NRRVIAVADD FCKVHLFQYP CSKAKAPSHK
YSAHSSHVTN VSFTHNDSHL ISTGGKDMSI IQWKLVEKLS LPQNEVIPDS SLTKAPASST
ENARQCNLPS QLLAETVEEE ERISSSPTLV ENSLEQTVEP SEEQSEGGSE DLGAMLDEEP
A
//
