ID A0A1A6H6H3_NEOLE Unreviewed; 469 AA.
AC A0A1A6H6H3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Clusterin {ECO:0000256|ARBA:ARBA00020334, ECO:0000256|RuleBase:RU000629};
DE Flags: Fragment;
GN ORFNames=A6R68_15550 {ECO:0000313|EMBL:OBS73911.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS73911.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS73911.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS73911.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS73911.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Cytoplasmic vesicle, secretory
CC vesicle, chromaffin granule {ECO:0000256|ARBA:ARBA00004248}.
CC Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Microsome
CC {ECO:0000256|ARBA:ARBA00004144}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004346}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004346}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004346}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the clusterin family.
CC {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS73911.1}.
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DR EMBL; LZPO01044571; OBS73911.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6H6H3; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR016016; Clusterin.
DR InterPro; IPR000753; Clusterin-like.
DR InterPro; IPR016015; Clusterin_C.
DR InterPro; IPR033986; Clusterin_CS.
DR InterPro; IPR016014; Clusterin_N.
DR PANTHER; PTHR10970; CLUSTERIN; 1.
DR PANTHER; PTHR10970:SF1; CLUSTERIN; 1.
DR Pfam; PF01093; Clusterin; 1.
DR PIRSF; PIRSF002368; Clusterin; 1.
DR SMART; SM00035; CLa; 1.
DR SMART; SM00030; CLb; 1.
DR PROSITE; PS00492; CLUSTERIN_1; 1.
DR PROSITE; PS00493; CLUSTERIN_2; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..42
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 43..469
FT /note="Clusterin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008346120"
FT DOMAIN 43..247
FT /note="Clusterin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00030"
FT DOMAIN 248..463
FT /note="Clusterin C-terminal"
FT /evidence="ECO:0000259|SMART:SM00035"
FT COILED 80..114
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OBS73911.1"
SQ SEQUENCE 469 AA; 54176 MW; 1921B5DB7E9D208C CRC64;
AHHQRHQEER SGATLQTGGR TMKILLLCVG LLLTWDNGMV LGEQEVSDNE LQEMSTQGSX
YINKEIQNAV QGVKQIKTLI EKTNAERKSL LNSLEEAKKK KEDALEDTRD SEMKLKAFPE
VCNETMMALW EECKPCLKQT CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID
SLMESDRQQN QALDAMQDSF TRASGIMDML FQDRFFTHEP QDTHFFSPFG FPHRRPHFLY
PKSRLVRSLM PLSHYGPLSF HDMFQPFFEM IHQAQQAMDV QFHSPAFQFP XVDFIREGED
DRAVCKEIRH NSTGCLKMKS QCEKCQEILS VDCSANNPAQ AHLRQELNDS LQVAEMLTQK
YNELLHSFQT KMFNTSSLLE QLNDQFNWVS QLANLTQGED QYYLRVSTVT THSSDSEVPS
RVTEVVVKLF DSDPITVVLP EEVSRDNPKF MDTVAEKALQ EYRKKSRVE
//
