ID A0A1A6H7N7_NEOLE Unreviewed; 744 AA.
AC A0A1A6H7N7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Thrombospondin 2 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=A6R68_15845 {ECO:0000313|EMBL:OBS73617.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS73617.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS73617.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS73617.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS73617.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS73617.1}.
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DR EMBL; LZPO01045123; OBS73617.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A6H7N7; -.
DR STRING; 56216.A0A1A6H7N7; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR028974; TSP_type-3_rpt.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR10199; THROMBOSPONDIN; 1.
DR PANTHER; PTHR10199:SF10; THROMBOSPONDIN-2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF00090; TSP_1; 3.
DR Pfam; PF02412; TSP_3; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00209; TSP1; 3.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF103647; TSP type-3 repeat; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50092; TSP1; 3.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 300..357
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 531..571
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 630..674
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 709..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..731
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OBS73617.1"
SQ SEQUENCE 744 AA; 81578 MW; A04CE5A5822AA6AB CRC64;
GDQGEDTSFD LFSISNINRK TIGAKQFRGP DPGVPAYRFV RFDYIPPVKT EDLSRIVKLA
KRKEGFFLTA QLKQDRKSRG TLLVLEGPST SQRQFEIVSN GPGDTLDLNY WIEGTQHTNF
LEDVGLADSQ WRNVTVQVAS DTYSLYVGCD LIDSVTLEEP FYEQLQADRS RMYVAKGASR
ESHFRGLLQN VHLMFADSIE DILSKKGCQH SQGAEVNTIS EHTETLHLSP HITTDLVGQG
VEKTQEVCTH SCEELSNMMN ELSGLHVMVS QLSKNLERVS NDNQFLLELI GGPLKTRNMS
ACVQEGRIFA ENETWVVDSC TTCTCKKFKT VCHQITCSPA TCANPSFVEG ECCPSCSHSS
DNDEDWSPWA EWTECSVTCG SGTQQRGRSC DVTSNTCLGP SIQTRACSLG KCDTRIRQNG
GWSHWSPWSS CSVTCGVGNV TRIRLCNSPV PQMGGKNCKG SGRETKTCQG IPCPIDGRWS
PWSPWSACTV TCAGGIRERT RVCNSPEPQY GGKDCVGDVK EHQMCNKRSC PIDGCLSNPC
FPGAKCNSFP DGSWSCGSCP VGFLGNGTHC EDLDECAVAT DICFSTNKVS RCVNTNPGFH
CLPCPPRYKG SQPFGVGLEA ARTEKQVCEP ENPCKDKTHN CHKHAECIYL GHFSDPMYKC
ECQTGYAGDG LICGEDSDLD GWPNSNLVCA TNATYHCIKD NCPKLPNSGQ EDFDKDGIGD
ACDEDDDNDG VSDEKVGWAL LSNT
//
