ID A0A1A6H928_NEOLE Unreviewed; 776 AA.
AC A0A1A6H928;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein {ECO:0000259|SMART:SM00014};
DE Flags: Fragment;
GN ORFNames=A6R68_14681 {ECO:0000313|EMBL:OBS74811.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS74811.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS74811.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS74811.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS74811.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC family. {ECO:0000256|ARBA:ARBA00008816}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS74811.1}.
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DR EMBL; LZPO01044393; OBS74811.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A6H928; -.
DR STRING; 56216.A0A1A6H928; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR CDD; cd03384; PAP2_wunen; 1.
DR Gene3D; 1.20.144.10; Phosphatidic acid phosphatase type 2/haloperoxidase; 1.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR InterPro; IPR043216; PA_PP_rel.
DR PANTHER; PTHR10165; LIPID PHOSPHATE PHOSPHATASE; 1.
DR PANTHER; PTHR10165:SF14; PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 3; 1.
DR Pfam; PF01569; PAP2; 1.
DR SMART; SM00014; acidPPc; 1.
DR SUPFAM; SSF48317; Acid phosphatase/Vanadium-dependent haloperoxidase; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..304
FT /note="Phosphatidic acid phosphatase type 2/haloperoxidase"
FT /evidence="ECO:0000259|SMART:SM00014"
FT REGION 339..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..488
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 776
FT /evidence="ECO:0000313|EMBL:OBS74811.1"
SQ SEQUENCE 776 AA; 83210 MW; D1F453E1A3ABA7E8 CRC64;
MIAMKEKNKT PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV GFQCYDRSLS
MPYVETNEEL IPLLMLLSLA FAAPAASIMV GEGMVYCLQS RLWGRSSGGA EGSINAGGCN
FNSFLRRTVR FVGVHVFGLC ATALVTDVIQ LATGYHTPFF LTVCKPNYTL LGTSCEANPY
ITQDICSGHD THAILSARKT FPSQHATLSA FAAVYVSVSE SPQCCTLCPP VGSSYNLDPA
YLLAQMYFNS VISDTTKLLK PILVFAFAIA AGVCGLTQIT QYRSHPVDVY AGFLIGAGIA
AYLACHAVGN FQAPTAEKVS VPAPAKDALR ALTQRGHESM YQQNKAVSTD ELGPPGRLEG
VPRPVAREKT SLGSLKRASV DVDLLAPRSP MGKEGMVTFS NTLPRVSTPS LDDPARRHMT
IHVPLDASRS KQLISEWKQK SLEGRGLGLP DEGSPVHLRA PAEPMAEEEE EEEEEEEEEE
EEEEEEGPVP PSLYPTVQAR PGLGPRVILP PRPGPQPLVH IPEEGVQAGA GLSPKSSSSV
RAKWLSMAEK GGAPVAVAPS QPRVANPPRL LQVIAMSKAA GGPKAETASS SSASSDSSQY
RSPSDRDSAS IVTIDAHAPH HPVVHLSAGS TPWEWKAKVV EGDGSYELGD LARGFRSSCK
QPSMGPGSPV SDVDQEEPRF GAVATVNLAT GEGLPPPGAS DGAMGAGSRE STLRRQVGGL
GDREVEAEAE SYYRRMQARS NNRKQKNRAV SWQRNSGSGK KKNWEGRGGK KKVAKH
//
