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Database: UniProt
Entry: A0A1A6HI37_NEOLE
LinkDB: A0A1A6HI37_NEOLE
Original site: A0A1A6HI37_NEOLE 
ID   A0A1A6HI37_NEOLE        Unreviewed;       401 AA.
AC   A0A1A6HI37;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   03-JUL-2019, entry version 16.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OBS77630.1};
DE   Flags: Fragment;
GN   ORFNames=A6R68_19981 {ECO:0000313|EMBL:OBS77630.1};
OS   Neotoma lepida (Desert woodrat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Neotominae; Neotoma.
OX   NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS77630.1, ECO:0000313|Proteomes:UP000092124};
RN   [1] {ECO:0000313|EMBL:OBS77630.1, ECO:0000313|Proteomes:UP000092124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=417 {ECO:0000313|EMBL:OBS77630.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:OBS77630.1};
RA   Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT   "The Draft Genome Sequence and Annotation of the Desert Woodrat
RT   Neotoma lepida.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OBS77630.1}.
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DR   EMBL; LZPO01028630; OBS77630.1; -; Genomic_DNA.
DR   Proteomes; UP000092124; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR008061; K_chnl_inward-rec_Kir5.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF24; PTHR11767:SF24; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01678; KIR5CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000092124};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     78    100       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    149    174       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       42    178       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      186    352       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   SITE        165    165       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:OBS77630.1}.
FT   NON_TER     401    401       {ECO:0000313|EMBL:OBS77630.1}.
SQ   SEQUENCE   401 AA;  45759 MW;  E58AFBA7AB044AD6 CRC64;
     DQERMSYYGS SYRIVNVDSK HPGYPPEHAV AEKRRARRRL LHKDGSCNVY FKHIFGEWGS
     YMVDIFTTLV DTKWRHMFVI FSLSYILSWL IFGSIFWLIA FHHGDLLNDP GITPCVDNVH
     SFTAAFLFSL ETQTTIGYGY RCVTEECSVA VLTVILQSIL SCIINTFIIG AALAKMATAR
     KRAQTIRFSY FALIGMRDGK LCLMWRIGDF RPNHVVEGTV RAQLLRYSED GEGRMTMAFK
     DLKLVNDQII LVTPVTIVHE IDHEXPLYAL DRKAVAKDNF EILVTFIYTG DSTGTSHQSR
     SSYVPREILW GHRFNDVLEV KRKYYKVNCL QFEGSVEVYA PFCSAKQLDW KDQQLTSLEK
     TSPARGSCTS DTNVRRRSFS AVAIVSSCEN PEETTTSPPD E
//
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