ID A0A1A6HK84_NEOLE Unreviewed; 1196 AA.
AC A0A1A6HK84;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Small monomeric GTPase {ECO:0008006|Google:ProtNLM};
GN ORFNames=A6R68_18929 {ECO:0000313|EMBL:OBS78686.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS78686.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS78686.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS78686.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS78686.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS78686.1}.
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DR EMBL; LZPO01027395; OBS78686.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6HK84; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08855; ArfGap_AGAP3; 1.
DR CDD; cd04103; Centaurin_gamma; 1.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF2; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 585..823
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 844..964
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 1003..1035
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 56..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..107
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 129118 MW; B45B0D56B8DABD9A CRC64;
MERGWPPGES CCGERPAVCR RALSVCDSLD LXSAPTDRTA AALQAALCAA REQPARPRSV
CSGTPGSAPS GARGLLLGLL RPRHGRRGPA PSERPGSPAP SPEPSPAPAR RSRGSGERAS
RPRPTSMTFL EVNRLELAAT EAPGAGLGRT GSSGFLRGAS LWSSQRWQVF RGGGGRSAES
PRRGLSALRK SFSFRLRRGQ EIRRSESGLL ARPPRARTRS DGDASSLGTF PSRRDLLGAD
APCAXPEPGR PRAAASLWKL LTSRFRRREP APAAPLWSRR AAAAPGLLGA SSDSFVNSQE
WTLSRSVPEL KVGIVGNLSS GKSALVHRYL TGTYVQEESP EGGRFKKEIV VDGQSYLLLI
RDEGGPPELQ FAAWVDAVVF VFSLEDEISF QTVYNYFLRL CSFRNASEVP MVLVGTQDAI
SAANPRVIDD SRARKLSTDL KRCTYYETCA TYGLNVERVF QDVAQKVVAL RKKQQLAIGP
CKSLPNSPSH SAVSAASIPA VHINQATNGG SSAFSDYSSS VPSTPSISQR ELRIETIAAS
STPTPIRKQS KRRSNIFTSR KGADLDREKK AAECKVDSIG SGRAIPIKQG ILLKRSGKSL
NKEWKKKYVT LCDNGLLTYH PSLHDYMQNI HGKEIDLLRT TVKVPGKRLP RATPTTAPGT
SPRANGLAME RSNTQLGGGA GAPHSASSAS LHSERPHSSS AWAGLRPQGL HQRSCSVSSA
DQWSEAAALP ASMQHPASGP AEVLSSSPKL EPPPSPHSNR KKHRRKKSTT GTPRPDGPSS
AAEEAEESFE FVVVSLTGQT WHFEASTAEE RELWVQSVQA QILASLQGCR SAKDKTRLGN
QNTALAVQAV RTVRGNSFCI DCEAPNPDWA SLNLGALMCI ECSGIHRHLG AHLSRVRSLD
LDDWPPELLA VMTAMGNALA NSVWEGALDG YSKPGPEACR EEKERWIRAK YEQKLFLAPL
PSSDVPLGQQ LLRAVVEDDL RLLVMLLAHG SKEEVNETYG DGDGRTALHL SSAMANVVFT
QLLIWYGVDV RSRDARGLTP LAYARRAGSQ ECADILIQHG CPGEGCGLAP TPNREPANGT
NPSAELHRSP KGPEGLHGLE ETDGEAGVCS EEEEEERRRV QGWRRGLRFE LQQSRSVLCS
PLPYGAVKGQ NPLEVPVRRG GQDLSLLQNP ASSRQLPQAF TLQWVGKDRI QDGGAS
//