ID A0A1A6HMC9_NEOLE Unreviewed; 933 AA.
AC A0A1A6HMC9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
DE Flags: Fragment;
GN ORFNames=A6R68_18197 {ECO:0000313|EMBL:OBS79446.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS79446.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS79446.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS79446.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS79446.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. ICAM family.
CC {ECO:0000256|ARBA:ARBA00005925}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS79446.1}.
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DR EMBL; LZPO01020470; OBS79446.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A6HMC9; -.
DR STRING; 56216.A0A1A6HMC9; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003988; ICAM.
DR InterPro; IPR048679; ICAM1_3_5_D2.
DR InterPro; IPR013768; ICAM_N.
DR InterPro; IPR047012; ICAM_VCAM.
DR InterPro; IPR003987; ICAM_VCAM_N.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR13771; INTERCELLULAR ADHESION MOLECULE; 1.
DR PANTHER; PTHR13771:SF9; INTERCELLULAR ADHESION MOLECULE 5; 1.
DR Pfam; PF21146; ICAM1_3_5_D2; 1.
DR Pfam; PF03921; ICAM_N; 1.
DR Pfam; PF13927; Ig_3; 1.
DR PRINTS; PR01473; ICAM.
DR PRINTS; PR01472; ICAMVCAM1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..875
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 279..370
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 460..538
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 682..755
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 762..845
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 140..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 933
FT /evidence="ECO:0000313|EMBL:OBS79446.1"
SQ SEQUENCE 933 AA; 99657 MW; 1AD538DAF9BE88F9 CRC64;
MPDKREEKEA QSNLFRFSCW INKAFFLGLR RALLGLWAAL GLGILGISAV ALEPFWADLQ
PRMALVERGG SLWLNCSTNC PRPERGGLET SLRRNGTQRG LRWLARQLVD IREPETQPVC
FFRCARRTLQ ARGLIRTFRD SAHRSSRPPS HAQPGERYSS LEPKFRSLAE RPDRVELVPL
PPWQPVGENF TLSCRVPGAG PRASLTLTLL RGAQELTRRS FAGEPPRARG AVLTATVLAR
REDHGVNFSC LAELDLRPHG LGLFANSSAL RQLRTFALPP IPPSLVAPRF LEVGSERPVS
CTLDGLFPAP EAGVYLWLGD QRLHPDVTFD GDSLVATATA MPSAEQEGTR QLLCSVTLGG
ESRETQENLT VYSFPAPLLT LSEPEAPEGK VVTISCWAGP QALVTLEGIS AVVPGQPAEL
QLNVTENDDK RGFFCDAALE VDGETLRKNQ SAELRVLYSP RLDDSDCPRS WTWPEGPEQT
LHCEARGNPE PSVHCARPDG GAVLALGLLG PVTRALAGTY RCTAVNGQGQ AVKDVTLTVD
VTCVRSGKDE LMEGLLRVAR EHAGIYRCEA INARGSAAKN VVVTVEYGPS FEELSCPSNW
TWVEGSGRLF SCEVDGKPEP RVECLGSEGA SKGVVLPLVS SNHGPRNSMT SSNLSPGIYL
CNATNRHGST VKTVVVSAES PPQMDESSCP SHQTWLEGAE ATALTCSARG RPSPRVRCSR
EGAARLERLH VSREDAGTYR CVATNAHGTD SRTVTVGVEY RPVVAELAAS PPSVRPGGNF
TLTCRAEAWP PAQISWRAPP GALNLGLSSN NSTLSVAGAM GSHGGEYECA ATNAHGRHAR
RITVRVAGPW LWVAVGGAAG GAALLAAGAG LAFYVQSTAC KKGEYNVQEA ESSGEAVCLN
GAGGTPGSEG GAETAGTAES PADGEVFAIQ LTA
//
