ID A0A1A6HMD5_NEOLE Unreviewed; 1596 AA.
AC A0A1A6HMD5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Dedicator of cytokinesis protein 6 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=A6R68_18202 {ECO:0000313|EMBL:OBS79451.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS79451.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS79451.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS79451.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS79451.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS79451.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LZPO01020470; OBS79451.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6HMD5; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF65; DEDICATOR OF CYTOKINESIS PROTEIN 6; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF14429; DOCK-C2; 2.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124}.
FT DOMAIN 458..680
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1487..1596
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1596
FT /evidence="ECO:0000313|EMBL:OBS79451.1"
SQ SEQUENCE 1596 AA; 176583 MW; 677B188B0AAFA082 CRC64;
MILEGLVDQK EDFDPKTVAA EVRKQVSRER SGSPHSSRRS SSSLGVPLTE VIEPLDFEDV
LLSRPPEVEP GPLRDLIEFP ADDLELLKQP RECRTTESGV PEDGCLDAQV RAAVEMYSED
WVIVRRRYQH LSTAYSPVTT ETLRERQKGL TCQVFEQDTS GDERMGPEDT DDSQHCSGSP
DDTPRSSGAS GIFSLRNLAS DSLLPALLER AAPEDVDRRN EALRQQHRAP ALLTLYPAPD
EDEAVERCSL PEPPREHFGQ RILVKCLSLK FEIEIEPIFG TLALYDVREK KKISENFYFD
LNSDSVKGLL RAHGTHPAIS TLARSAVFSV TYPSPDIFLV VKGAKESLAG SFVLQLEKVL
QQGDISECCE PYMVMKEADA VKNKEKLERL RLAAEQFCTR LGRYRMPFAW TAVHLANIVX
SVGPQDRDSD SESGLKFLVG LAQPGTSQLD LESPYSVPNL LFVYPHSLNF SSRQGSVRNL
AVRIQYMAGE DQSQALPVIF GKSSCSEFTR EAFTPVVYHN KYAGLGMRHG LTLGISEGSP
EFYEEFKLRL PACVTENHHL FFTFYHVSCQ PRPGTALETP VGFTWIPLLQ HGRLRTGPFC
LPVSVDQPPP SYSVLTPDVR PVPPTPTPSF PLAYGLAWWP DAWGRVSLCP PRPSLPQVAL
PGMRWVDGHK GVFSVELTAV SSVHPQDPHL DKFFTLVHVL EEGTFPFRLK ETVLSEATVE
QELRASLAAL RLASPEPLVA FSHHVLDKLV RLVVRPPIIG GQIVNLGRGA FEAMAHVASL
VHRSLETIQD SRGHCPLLAA YVHYAFRLPG GDLSLPGGVP PATIQAATLA RGSGRPASLY
LTRSKSISSS NPDLAIVPGS VDDEVSRILA TKGVDRSHSW VNSAYAPGGT KAVLRRVPPY
CGAEPRQAID RNSSRASSYL EASSSALPAP QPRFTVQKLL HEELALQWVV SGSAVREVAL
QHAWFFFQLM VKSMELHLLL GQRLDTPRKL RFPGRFLDDI AALVASVGLE VITRVHKDME
LAERLNASLA FFLSDLLSIA DRGYIFSLVR AHYKQVTTRL QSAPNPAALL TLRMDFTRIL
CSHEHYVTLN LPCCPLSPPA SPSPSVSSTT SQSSTFSSQA PDPKVTSMFE LSGPFRQQHF
LSGLLLTELA LALEPEAEGA SLLHKKAISA VHSLLCSHDV DSRYTEPTVK AKVAELYLPL
LSLARDTLPR LHGFAGQRAG EDGAARSGCP LSAESSRTLL VCVLWVLKNA EPALLQRWTA
DLALPQLGRL LDLLYLCLAA FEYKREVHLE TKRMFAGVRV SLTGDRPQTV WTSKTKDEME
HEALVDGNLA TEASLVVLDT LEIIVQFPEL LFEEDTELCA DLCLRLLRHC GSRISIIRTH
ASASLYLLMR QNFEIGHNFA RVKMLVTMSL SSLVGTTQNF SEEHLRRSLK TILTYAEEDI
GLRDSTFAEQ VQDLMFNLHM ILTDTVKMKE HQEDPEMLMD LMYRIARGYQ GSPDLRLTWL
QNMAGKHAEL GNHAEAAQCM VHAAALVAEY LALLEDSRHL PVGCVSFQNV SSNVLEESAI
SDDILSPDEE GFCSGKNFTE LGLVGLLEQA AAYFTM
//
