ID A0A1A6HRX3_NEOLE Unreviewed; 749 AA.
AC A0A1A6HRX3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 13-SEP-2023, entry version 17.
DE RecName: Full=Macro domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=A6R68_20803 {ECO:0000313|EMBL:OBS81006.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS81006.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS81006.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS81006.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS81006.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS81006.1}.
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DR EMBL; LZPO01017298; OBS81006.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6HRX3; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
DR CDD; cd02907; Macro_Af1521_BAL-like; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 2.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR PANTHER; PTHR14453; PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14453:SF70; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP9; 1.
DR Pfam; PF01661; Macro; 2.
DR SMART; SM00506; A1pp; 2.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52949; Macro domain-like; 2.
DR PROSITE; PS51154; MACRO; 2.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000092124}.
FT DOMAIN 116..292
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 284..434
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 557..745
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT NON_TER 749
FT /evidence="ECO:0000313|EMBL:OBS81006.1"
SQ SEQUENCE 749 AA; 83871 MW; 495C44A602E81C03 CRC64;
MAVGVWLATV APGSGAAAHP ERPGMTASLS LLFKKSFAEL FPHCRRGRPE GDCLPLRGSA
NDSLXEHNRW QIPIKHXVFH VFKSNEYQLC EVLRNKFGCI STLSCPTRAG NSTPAQQVFR
RRLTPGIELS VWKDDLTRHV VDAVVNAANE ELWHGGGLAG SLVKAGGSEI QEESRIXIET
YGRLPCNWII HAVGPQWTAV DSQTAIQLLR LAVKNILDYV CLQDTQIKTV AIPALSSGIF
QFPLDLCTRT ILETIRFYFQ GKQPISDLKE IHLVSNEDLT VASFKDTAES ILGKEELSPW
GXPQTTLSSN TDVIVNSGYK HHLKTGSVSQ SILKQAGVEM ERELDKITWY PDYQTVLVTK
GFKLACQYVF HVILKDAMKS CLEKCLQPNI NSISFPALGT GVIDIEKSTA ARIMLDEIVA
FAKEHMKKTL TVKIVIFPKD VETYKWTRGE QRSGFEAGSP AINLMGVKVE EMCEAKEWIE
RLLTSKDRYI IENSHILYLG KKEHDTLSQL QATLGVSISE TVSPRKATLE IXGAQADLFE
AVTKVECMLC EVQEEWTDQQ GKMDKMEEFH TYLRYPVPLT QELEDKKRQF EKCGLWVVKV
GQIDNDVLMA AFQEKKKMME GRTPKGXGSQ RLFQQVPYQF CNVSLKKLAD QVKKTSSTDR
LIYVFEAEVL TGSYCQSNSL NITPPPLSPG ALDAHDSVVD SVSNPETIVV FSGVQAMPQY
LWICTQDRSL SQHQMWGQDY SLGLESWQG
//
