ID   A0A1A6HSL0_NEOLE        Unreviewed;       716 AA.
AC   A0A1A6HSL0;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   ORFNames=A6R68_20610 {ECO:0000313|EMBL:OBS81209.1};
OS   Neotoma lepida (Desert woodrat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Neotominae; Neotoma.
OX   NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS81209.1, ECO:0000313|Proteomes:UP000092124};
RN   [1] {ECO:0000313|EMBL:OBS81209.1, ECO:0000313|Proteomes:UP000092124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=417 {ECO:0000313|EMBL:OBS81209.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:OBS81209.1};
RA   Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT   "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT   lepida.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBS81209.1}.
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DR   EMBL; LZPO01017287; OBS81209.1; -; Genomic_DNA.
DR   STRING; 56216.A0A1A6HSL0; -.
DR   Proteomes; UP000092124; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF22; ANOCTAMIN-7; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 2.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        321..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        360..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        396..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        426..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        518..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        569..593
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        650..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          39..253
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          256..359
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   DOMAIN          430..693
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   716 AA;  81217 MW;  116F91086A43058B CRC64;
     MILTSHHSPV PPLRPSNPTV GLHSISPHSL PVFSLIPADF VLVWEEDLRN QEGPTQNKTD
     THEVWRETFL ENLRLAGLNV DQDEATAVHY ILLRAPWAVL CYYAEDLRLX LPLQELPNQA
     SNWSATLLEC LGIPNILLEH VPDTPPEYYS CQFKASKLQW FLGSDNQDTF FSSTKRHQIL
     FEILAKTQYG HEKKGFFGID QLLAEGVFSA AFPLHDGPFS AVPENSQVLG LTQRQVLFQH
     WARWGKWSKY QPLDHVRRYF GEKVALYFAW LGESCLAARE ELCHSSDGFD MCPLCPDCSF
     WLLSSACTLA QAGRLFDHGG TVFFSLFMAL WAVLLLEYWK RKNATLAYRW DCSDYEDIEV
     AVVIMCLVSI ILYRAIMAVL VSKSDNVFLS AWAPRIASLT GSVVNLIFIV ILSKVYVVLA
     QVLTRWVVLL QCAAGGCLIE LAQELLVIMV GKQIINNVQE VLVPKLKGCW QKLYSRRRKA
     GMGAHPAPWE ADYELLPCEG LFHEYLEMAP ASGYSCPAVL QFGFVTIFVA ACPLAPLFAL
     LNNWVEIRLD ARKFVCEYRR PVAERAQDIG IWFHILAGLT HLAVISNAFL LAFSSDFLPR
     AYYRWTRAPD LRGFLNFTLA RAPPAFAAAH NRTCRYRAFR DDDGHYSQTY WTLLAIRLAF
     VIVFEHVVFS IGRLLDLLVP DIPESVEIKV KREYFLAKQA LAENEVSLQA LTLMLS
//