ID A0A1A6HUD6_NEOLE Unreviewed; 1205 AA.
AC A0A1A6HUD6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
DE Flags: Fragment;
GN ORFNames=A6R68_24171 {ECO:0000313|EMBL:OBS81839.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS81839.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS81839.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS81839.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS81839.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS81839.1}.
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DR EMBL; LZPO01009017; OBS81839.1; -; Genomic_DNA.
DR STRING; 56216.A0A1A6HUD6; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 11.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 11.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722:SF11; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 11.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00192; LDLa; 11.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 11.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 11.
DR PROSITE; PS51120; LDLRB; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 93..108
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT DOMAIN 134..149
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 197..239
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 346..389
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 666..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 545..557
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 552..570
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 586..598
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 593..611
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 627..639
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 634..652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 748..763
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 774..786
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 781..799
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 793..808
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 813..825
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 820..838
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 832..847
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 852..864
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 859..877
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 871..886
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 896..908
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 903..921
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 945..963
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 982..994
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 989..1007
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OBS81839.1"
FT NON_TER 1205
FT /evidence="ECO:0000313|EMBL:OBS81839.1"
SQ SEQUENCE 1205 AA; 135276 MW; 9E2A62A2547647AC CRC64;
SLEIALLPSL PVEMTDLRTG GAFPGLGSVM AIQTVLTPLM SYRTAPGEPA LEENSPAPNS
VYLGDFRSIN ECLDSSISRC DHNCTDTITS FYCSCLPGYK LMSDKRTCVD IDECKESPQL
CSQKCENVIG SYICKCXPGY IREPDGKTCR QNSNIEPYLI FSNRYYLRNL TTDGAFYSLI
LQGLGNVVAL DFDRVEKRLY WIDTEKQIIE RMFLNKTNRE TIVRHRLLRA ESLAVDWVSR
AHARLAVYVG TLGLQKYTAV PLLFVAFEKL YWLDAVLDCL FVSDLEGRHR KMLAQHCVDA
NNTFCFENPR GIVLHPQNGY CPSVILYPSP CIHSPVHVAA YGRETLHVYW ADWGSRAYIA
RVGMDGANKS VIISTKIEWP NAITIDYTND LLFSDLDGHH RQTVYDGTLP HPFAITIFED
TVYWTDWNTR TVEKGNKYDG SDRAVLDFEK QQRTTIVNNP CGTNNGGCSH LCLIKAGGKG
FTCECPDDFQ IVHLRGQTLC MPMCSSTQFL CGNNEKCIPI WWKCDGQKDC LDGSDEPDLC
PHRFCRLGQF QCRDGNCTSP QALCNAHQDC ADGSDEDHGL CDHHRCESNQ WQCANRRCIP
EAWQCDSVND CQDNSDEDSL RCASRTCKPG QFRCNNGRCI PQSWKCDVDN DCGDYSDEPI
HECSEFPGGS HAKPELGGKQ MAPPPQPKGR GTTSNRDACR QRLFSGYVVN IDRPCPLYNH
MSAAYNCDNH TEFSCKTNYR CIPQWAVCNG ADDCRDNSDE QDCGRKGSRE ALPCTPGNFR
CRNHHCIPLR WKCDAYDDCG DNSDEENCVP RECTESEFRC VDQQCIPSRW VCDQENDCGD
NSDERDCEMK TCHPEHFQCA SGHCVPSSLA CDGRADCLDA SDESSCPTRF PNGTYCPAAM
FECKNHVCIQ SFWICDGEND CVDGSDEELH LCFNVPCESP HRFRCDNSRC IYGHQLCNGV
DDCGDGTDEK EEHCKNPTHK PCTETEYKCT NGHCISEHYV CDNVDDCGDL SDETDLGENR
TCAENICEQN CTQLSNGGFI CSCSPGFKSS TLDKNSCQDI NECEQFGICP QSCRNSKGSY
ECFCADGFKS MSSHYGERCA ADANPPLLLL PENVRIRKYN VSSEKFSEYL EEEEHIQALD
YDWDPEGMDL SVVYYTVLGQ GSEFGAIKRA YIPDFESGSN NPMRAVDLGL KYIMQPDGLA
VDWVG
//
