ID   A0A1A6HVH8_NEOLE        Unreviewed;       908 AA.
AC   A0A1A6HVH8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Arsenite-resistance protein 2 {ECO:0000256|ARBA:ARBA00033161};
GN   ORFNames=A6R68_23778 {ECO:0000313|EMBL:OBS82229.1};
OS   Neotoma lepida (Desert woodrat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Neotominae; Neotoma.
OX   NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS82229.1, ECO:0000313|Proteomes:UP000092124};
RN   [1] {ECO:0000313|EMBL:OBS82229.1, ECO:0000313|Proteomes:UP000092124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=417 {ECO:0000313|EMBL:OBS82229.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:OBS82229.1};
RA   Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT   "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT   lepida.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ARS2 family.
CC       {ECO:0000256|ARBA:ARBA00005407}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBS82229.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LZPO01008120; OBS82229.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A6HVH8; -.
DR   STRING; 56216.A0A1A6HVH8; -.
DR   Proteomes; UP000092124; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039727; SE/Ars2.
DR   InterPro; IPR007042; SERRATE/Ars2_C.
DR   InterPro; IPR021933; SERRATE/Ars2_N.
DR   PANTHER; PTHR13165; ARSENITE-RESISTANCE PROTEIN 2; 1.
DR   PANTHER; PTHR13165:SF0; SERRATE RNA EFFECTOR MOLECULE HOMOLOG; 1.
DR   Pfam; PF04959; ARS2; 1.
DR   Pfam; PF12066; SERRATE_Ars2_N; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092124}.
FT   DOMAIN          153..262
FT                   /note="SERRATE/Ars2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12066"
FT   DOMAIN          645..883
FT                   /note="SERRATE/Ars2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04959"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          865..886
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..347
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..382
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..411
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   908 AA;  103818 MW;  5708863F88B3CF30 CRC64;
     MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR SRGEYRDYDR
     NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYDMPY AGGGGGPTYG PPQPWGHPDV
     HIMQHHVLPI QARLGSIAEI DLGVPPPVMK SFKEFLLSLD DSVDETEAVK RYNDYKLDFR
     RQQMQDFFLA HKDEEWFRSK YHPDEVGKRR QEARGALQNR LKVFLSLMES GWFDNLLLDI
     DKADAIVKML DAAVIKMEGG TENDLRILEQ EEEEEQAGKT GEASKKEEGR AGPGPGDGER
     KVNDKDEKKE EGKQAENDSS NDDKTKKSEG DGDKEEKKEE AEKEAKKSKK RNRKHSGDDS
     FDEGSVSESE SESESGQAEE EKEEAEEALK EKEKPKEEER EKPKDAAGLE CKPRPLHKTC
     SLFMRNIAPN ISRAEIISLC KRYPGFMRVA LSEPQPERRF FRRGWVTFDR SVNIKEICWN
     LQNIRLRECE LSPGVNRDLT RRVRNINGIT QHKQIVRNDI KLAAKLIHTL DDRTQLWASE
     PGTPPVPTSL PSQNPILKNI TDYLIEEVSA EEEELLGSSG GPPPEEPPKE GNPAEMNVER
     DEKLIKVLDK LLLYLRIVHS LDYYNTCEYP NEDEMPNRCG IIHVRGPMPP NRISHGEGTL
     QVPPSCLLCP TSVFSCPSSL PAPSSLSSSS VIRIVLEWQK TFEEKLTPLL SVRESLSEEE
     AQKMGRKDPE QEVEKFVTSN TQELGKDKWL CPLSGKKFKG PEFVRKHIFN KHAEKIEEVK
     KEVAFFNNFL TDAKRPALPE IKPAQPPGPA QSLTPGLPYP HQTPQGLMPY GQPRPPILGY
     GAGAVRPAVP TGGPPYPHAP YGAGRGNYDA FRGQGGYPGK PRNRMVRGDP RAIVEYRDLD
     APDDVDFF
//