ID A0A1A6HVU5_NEOLE Unreviewed; 775 AA.
AC A0A1A6HVU5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Zinc phosphodiesterase ELAC protein 2 {ECO:0000256|ARBA:ARBA00013357};
DE EC=3.1.26.11 {ECO:0000256|ARBA:ARBA00012477};
DE AltName: Full=ElaC homolog protein 2 {ECO:0000256|ARBA:ARBA00032616};
DE AltName: Full=Ribonuclease Z 2 {ECO:0000256|ARBA:ARBA00030729};
DE AltName: Full=tRNA 3 endonuclease 2 {ECO:0000256|ARBA:ARBA00032104};
DE AltName: Full=tRNase Z 2 {ECO:0000256|ARBA:ARBA00030689};
GN ORFNames=A6R68_23875 {ECO:0000313|EMBL:OBS82135.1};
OS Neotoma lepida (Desert woodrat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Neotoma.
OX NCBI_TaxID=56216 {ECO:0000313|EMBL:OBS82135.1, ECO:0000313|Proteomes:UP000092124};
RN [1] {ECO:0000313|EMBL:OBS82135.1, ECO:0000313|Proteomes:UP000092124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=417 {ECO:0000313|EMBL:OBS82135.1};
RC TISSUE=Liver {ECO:0000313|EMBL:OBS82135.1};
RA Campbell M., Oakeson K.F., Yandell M., Halpert J.R., Dearing D.;
RT "The Draft Genome Sequence and Annotation of the Desert Woodrat Neotoma
RT lepida.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of RNA, removing extra 3' nucleotides
CC from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy
CC group is left at the tRNA terminus and a 5'-phosphoryl group is left
CC at the trailer molecule.; EC=3.1.26.11;
CC Evidence={ECO:0000256|ARBA:ARBA00000402};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the RNase Z family.
CC {ECO:0000256|ARBA:ARBA00007823}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBS82135.1}.
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DR EMBL; LZPO01008206; OBS82135.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A6HVU5; -.
DR STRING; 56216.A0A1A6HVU5; -.
DR Proteomes; UP000092124; Unassembled WGS sequence.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0042781; F:3'-tRNA processing endoribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07718; RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; 1.
DR CDD; cd16296; RNaseZ_ELAC2-N-term-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 2.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR047151; RNZ2-like.
DR InterPro; IPR027794; tRNase_Z_dom.
DR PANTHER; PTHR12553; ZINC PHOSPHODIESTERASE ELAC PROTEIN 2; 1.
DR PANTHER; PTHR12553:SF49; ZINC PHOSPHODIESTERASE ELAC PROTEIN 2; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR Pfam; PF13691; Lactamase_B_4; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000092124};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 55..114
FT /note="tRNase Z endonuclease"
FT /evidence="ECO:0000259|Pfam:PF13691"
FT DOMAIN 466..672
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
FT REGION 15..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 86494 MW; 5E9E1F9E8DD4AC1A CRC64;
MWTLRSLLRP IGLRTMSQGS ARRPRPPKDP LRHLRTREKR GPSWGPRSPN TVYLQVVAAG
GRDAGAALYV FSEYNRYLFN CGEGVQRLMQ EHKLKVARLD NIFLTRMHWS NVGGLCGMIL
TLKETGLPKC VLSGPPQLEK YLEAIKIFSG PLKGIELAVR PHSAPEYEDE TMTVHQVPIY
CVNRKAGGRD PSLVVAFVCK LHLRKGTFLV LKAKELGLPV GTAAIAPIIA AVKDGQSITY
GGREIAPEEL CTPSDPGPVF IVVECPDEGF IQPICDNDTF KRYQGEADAP VALVVHIAPE
PVLTDSRYQQ WMESFGPDTQ HLILNENCPS VHNLRSHKIQ TQLSLIHPDI FPRLTSFYSK
EEGSALSMPT VRGECLLKYQ LRPKREWQRD TTLTCNTDEF IAEALELPNF QESVQEYNKG
MQESPAPEEK RSQYPEIVFL GTGSAIPMKI RNVSSTLINL SPDKSVLLDC GEGTFGQLCR
HYGQQIDRVL CNLAAVFVSH LHADHHTGLL NILLQREHAL VSEAPDIVLT EALYPMTVAT
VSAADSTRVN MIPAKCLQKG AEVSSPPVER LISLLLETCD LEEFQTCLVR HCKHAFGCAL
VHSSGWKVVY SGDTMPCEAL VQMGKDANLL IHEATLEDGM EEEAVEKTHS TTSQAINVGM
RMNADFIMLN HFSQRYAKIP LFSPDFNEKV GIAFDHMKVC FGDFPTVPKL IPPLKALFAD
DIEEMVERKE KRELRQVRAA LLAQQADSPE DTELQQKRAL TEEPHSPQSK KVRTQ
//