ID A0A1A7QS14_9FLAO Unreviewed; 797 AA.
AC A0A1A7QS14;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:RAJ27822.1};
GN ORFNames=LX77_00396 {ECO:0000313|EMBL:RAJ27822.1};
OS Gelidibacter algens.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Gelidibacter.
OX NCBI_TaxID=49280 {ECO:0000313|EMBL:RAJ27822.1, ECO:0000313|Proteomes:UP000248987};
RN [1] {ECO:0000313|EMBL:RAJ27822.1, ECO:0000313|Proteomes:UP000248987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12408 {ECO:0000313|EMBL:RAJ27822.1,
RC ECO:0000313|Proteomes:UP000248987};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAJ27822.1}.
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DR EMBL; QLLQ01000001; RAJ27822.1; -; Genomic_DNA.
DR RefSeq; WP_066438201.1; NZ_QLLQ01000001.1.
DR AlphaFoldDB; A0A1A7QS14; -.
DR STRING; 49280.A9996_17410; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000248987; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 8..206
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 209..308
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 797 AA; 88350 MW; 92F7B15C7B3D8D30 CRC64;
MSKRRIKKVA IIGSGIMGSG IACHFANIGV DVLLLDIVPR ELTDAEKAKG LTLEDKAVRN
RIVNDSLTAS LKSKPSPIYH PSFASRITTG NLEDDIAKVK DVDWIMEVVV ERLDIKKQVF
EKLEKYRTPG TLITSNTSGI PIHFMSEGRS EDFQKHFCGT HFFNPARYLK LFEIIPGPKT
SQEVLDFLKI YGEKFLGKTS VIAKDTPAFI GNRIGIFGIQ SLFHQVKEMD LTVEEVDKLT
GPVIGRPKSA TFRTVDVVGL DTLVHVANGI YENCPEDEAH ELFKLPDFIN TMMENKWLGS
KTGQGFYKKE GKDIRTLDLN TLEYRDRKSA KFATLELTKT VDKVVDRFPI LISGKDKAGE
FYRKNFAAMF AYVSNRIPEI TDELYKIDDA MKAGFGWEHG PFQIWDAVGV EKGIELIKAE
GLEPAAWVNE MLESGNKSFY TVKEGSTFFY DIPSKKQEKV PGQDAFIILD NIRKSKEVYK
NSGVVVEDLG DGILNVEFQS KMNTIGGDVL SGLNKAIDIA EKDFAGLVVG NQAANFSVGA
NIGMIFMMAA EQEYDELNAA IKYFQDSMMR MRYSAIPTIA APHGMALGGG CELSMHADKV
VAAAETYMGL VEFGVGVIPG GGGSKEMALR AQDLFRKGDV ELNTLQEYFL TIAMAKVSTS
AYEAFDLGVL QKGKDIIVVN KDRQLAMAKA HAKLMADAGY TQPIKRTDIK VLGRQALGMF
MVGTDAMEDS NYISAHDQKI ANKLAYVMAG GDLSEPTLVS EQYLLDLERE AFLSLATERK
TLERIQHMLK TGKPLRN
//
