ID A0A1A7R3T8_9FLAO Unreviewed; 765 AA.
AC A0A1A7R3T8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=LX77_00920 {ECO:0000313|EMBL:RAJ26665.1};
OS Gelidibacter algens.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Gelidibacter.
OX NCBI_TaxID=49280 {ECO:0000313|EMBL:RAJ26665.1, ECO:0000313|Proteomes:UP000248987};
RN [1] {ECO:0000313|EMBL:RAJ26665.1, ECO:0000313|Proteomes:UP000248987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12408 {ECO:0000313|EMBL:RAJ26665.1,
RC ECO:0000313|Proteomes:UP000248987};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAJ26665.1}.
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DR EMBL; QLLQ01000002; RAJ26665.1; -; Genomic_DNA.
DR RefSeq; WP_066431285.1; NZ_QLLQ01000002.1.
DR AlphaFoldDB; A0A1A7R3T8; -.
DR STRING; 49280.A9996_04235; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000248987; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RAJ26665.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..134
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 765 AA; 86712 MW; 0A05D80F661B1A52 CRC64;
MKVCIAEKPS VAREIATILG ANSKHDGYYE GNGYAVTYTF GHLCTLMEPN DYKPHWKSWD
LNNLPMLPEK FKTKVVSNSG IQKQFMIVKK LFDTADVVIN CGDAGQEGEL IQRWVLDQAN
YKGKVQRLWI SSLTAEAIKE GFENLKPSEQ YDNLFYAGFS RAIGDWLLGM NATRLYTLKH
GGYKQVLSVG RVQTPTLAMV VNRFKEIENF VPQPYWELQT LYRDTLFSYE EGRFTKMENG
EVLANKVKEH EFEIVSITKK KGKDYAPKLF DLTGLQVYCN TKFGFSADET LKIVQKLYEQ
KVVTYPRVDT TFLPNDIYPK VPGILSNLSK YASLTTPILG KKIKKSSKVF NDKKVTDHHA
IIPTGVESNL QYNQQQVYDI ITRRFIAVFY DDSTVSNTTV IGKAADVNFK ATGKEILSKG
WRVVFETANG TSGTAKENLL PSFVKGEKGS HEPSFLEKQT KPPNQFTEAS LLRAMETAGK
QVDDDEMREL MKENGIGRPS TRANIIETLF KRKYIERNKK QVLPTQIGIQ LIDTIQNELL
KSAELTGMWE KQLKDIEKGT YSAAQFIANM KKMVDALVYE VRSETQRANI SHIKIEDKAV
AKKEPKKKAG ITSITCPKCK NGTLITGKTA YGCSDFKNGC RFLLPFKFKD KKVSEKQYLR
LLQKGSTVNL KGFKNETGEL EGLIRFDDMF QLVLEPKKMA KKETSDSLTC PKCKKGTVIK
GKTAYGCSHY KEGCDFRFTF DDVRKKGEGK KMSKELVYSI LNGRI
//
