ID A0A1A7RA79_9GAMM Unreviewed; 674 AA.
AC A0A1A7RA79;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=A9J31_10350 {ECO:0000313|EMBL:OBX27617.1};
OS Acinetobacter gandensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1443941 {ECO:0000313|EMBL:OBX27617.1, ECO:0000313|Proteomes:UP000185753};
RN [1] {ECO:0000313|EMBL:OBX27617.1, ECO:0000313|Proteomes:UP000185753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ANC 4275 {ECO:0000313|EMBL:OBX27617.1,
RC ECO:0000313|Proteomes:UP000185753};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBX27617.1}.
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DR EMBL; LZDS01000029; OBX27617.1; -; Genomic_DNA.
DR RefSeq; WP_067767551.1; NZ_VZOF01000005.1.
DR AlphaFoldDB; A0A1A7RA79; -.
DR STRING; 1443941.A9J31_10350; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000185753; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 220..338
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 486..630
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 674 AA; 75018 MW; 3FE8D4A68433A068 CRC64;
MLNDISARRI RTLDPALANQ IAAGEVIERP ASVVKELLEN AIDAGSTELI IRVEQGGSTL
IEIIDNGRGI HHEDLPLAVM RHATSKIQSA EDLHAIVSLG FRGEALASIA AVSRLTLTSS
QNEDGVGYQV EVNGTAFDHQ EIQPVAAQRG TTIRVQDLFF NVPARRKFLK KQGTEFGHIE
EIVRRLALTH FDIRFVLEHN NSIKLNLPVA DSGALRFQRV QQLLGRQFTE NAYWIDADSV
NMRLSGWLGH PSDARAQADM QYVYVNGRIV KDKTVSHALR MAYDGILHGH QHAAYLLFME
VDPENIDVNV HPTKHEIRFL NQREVHEFVR HYAKSTLAQF QTATAELSSA MKLEPQAQEN
LIAQPRHQEQ FQLHQNIEAV TQTAANFVNP DSAGGLTDFS SPTGVNYAES AEQVAAYGYS
AAQHPSTGSI NTNGYVASYN GSKQLNNALQ SYLAPLRQTS DTAIDVEQSM QAHIQQKVDE
HPLGIAIAQL HGIYILAQNT EGLIIVDMHA AHERIVLQQM KTAWDKPEFW TSQQLLIPKV
VSISRMQAMR VDELKDQLAR LGLEIDQYGD EQVIVRGVPA ILHKADFDAL IPELLNDLDP
TDQVAGLLQK RDQILAGMAC HGAVRAHRIL SLSEMNALLR QMEQTEFASQ CNHGRPTWRA
FPLAQLDKLF ARGE
//
