ID A0A1A8VVC9_PLAMA Unreviewed; 334 AA.
AC A0A1A8VVC9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=FAD synthase {ECO:0000256|ARBA:ARBA00012393};
DE EC=2.7.7.2 {ECO:0000256|ARBA:ARBA00012393};
DE AltName: Full=FAD pyrophosphorylase {ECO:0000256|ARBA:ARBA00031145};
DE AltName: Full=FMN adenylyltransferase {ECO:0000256|ARBA:ARBA00031871};
GN Name=PmUG01_08031000 {ECO:0000313|EMBL:SCN12185.1};
GN ORFNames=PMALA_009940 {ECO:0000313|EMBL:SBS84515.1}, PMUG01_08031000
GN {ECO:0000313|EMBL:SCN12185.1};
OS Plasmodium malariae.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5858 {ECO:0000313|EMBL:SBS84515.1, ECO:0000313|Proteomes:UP000078597};
RN [1] {ECO:0000313|EMBL:SBS84515.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000078597}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Naeem Raeece;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SCN12185.1, ECO:0000313|Proteomes:UP000219813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + FMN + H(+) = diphosphate + FAD; Xref=Rhea:RHEA:17237,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:57692, ChEBI:CHEBI:58210; EC=2.7.7.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001332};
CC -!- PATHWAY: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step
CC 1/1. {ECO:0000256|ARBA:ARBA00004726}.
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DR EMBL; FLQW01000543; SBS84515.1; -; Genomic_DNA.
DR EMBL; LT594629; SCN12185.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A8VVC9; -.
DR VEuPathDB; PlasmoDB:PmUG01_08031000; -.
DR OMA; EEFVQWS; -.
DR OrthoDB; 5475801at2759; -.
DR Proteomes; UP000078597; Unassembled WGS sequence.
DR Proteomes; UP000219813; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003919; F:FMN adenylyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd01713; PAPS_reductase; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR002500; PAPS_reduct.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR23293:SF9; FAD SYNTHASE; 1.
DR PANTHER; PTHR23293; FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE; 1.
DR Pfam; PF01507; PAPS_reduct; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:SCN12185.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000219813};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SCN12185.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 253..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 115..295
FT /note="Phosphoadenosine phosphosulphate reductase"
FT /evidence="ECO:0000259|Pfam:PF01507"
SQ SEQUENCE 334 AA; 40156 MW; D59CE4ECC1C0AA1A CRC64;
MNAEDKEEWN DYSNSLMLYE QIEKLHNEYN REIKILKDCN NKELSNCDVL FYGENKNAQV
IKSRDIIKPS MYNYDVINYY KDEVTLKKKI MELSEDIMTA IYHIYDSLRL CKENVFLSFN
GGKDAVVVLH LFRCAYARYL YDVKGERKKP KLIYFKDDIS EFPEVYHFLN ECVYMYDFNI
SVIKGTWRSS ITNFVENYQK QYQIVMTDQM KVSPNDSCPF FPIITFINGT RYNDTYSEKL
QILNISSREF PPYLYLNPIF YWTYGAIWTF ILYFKFDYCI LYDHGYSSIG SLNDTIKNEF
LKCNDCYLPA YFLKNWGYER HNRVLNEEKK VRDS
//
