ID A0A1A8VWL3_PLAMA Unreviewed; 922 AA.
AC A0A1A8VWL3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Carnosine N-methyltransferase {ECO:0000256|ARBA:ARBA00015448};
DE EC=2.1.1.22 {ECO:0000256|ARBA:ARBA00012003};
GN Name=PmUG01_08046900 {ECO:0000313|EMBL:SCN12341.1};
GN ORFNames=PMALA_011020 {ECO:0000313|EMBL:SBS84893.1}, PMUG01_08046900
GN {ECO:0000313|EMBL:SCN12341.1};
OS Plasmodium malariae.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5858 {ECO:0000313|EMBL:SBS84893.1, ECO:0000313|Proteomes:UP000078597};
RN [1] {ECO:0000313|EMBL:SBS84893.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000078597}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Naeem Raeece;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SCN12341.1, ECO:0000313|Proteomes:UP000219813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the carnosine N-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010086}.
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DR EMBL; FLQW01000603; SBS84893.1; -; Genomic_DNA.
DR EMBL; LT594629; SCN12341.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A8VWL3; -.
DR VEuPathDB; PlasmoDB:PmUG01_08046900; -.
DR OMA; SMCAGEL; -.
DR OrthoDB; 167229at2759; -.
DR Proteomes; UP000078597; Unassembled WGS sequence.
DR Proteomes; UP000219813; Chromosome 8.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR InterPro; IPR012901; CARME.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12303:SF6; CARNOSINE N-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12303; UNCHARACTERIZED; 1.
DR Pfam; PF07942; CARME; 1.
DR SMART; SM01296; N2227; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000219813};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..627
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 105567 MW; 2E0F3595B8228D36 CRC64;
MMSDGMNEIR ADKSVSPSGI SDSGRSSGSG RISGSGCSRG SGCSRGSGRS SGSGRSSGSE
GSQGGSNSDE KNGKKSNSIC RRGEDTLDRG NNNTSKEKSK GKESKQMVYG NSYSNLENSN
NFINEIQCSE HCNDNTEILN YEEEKHFCNV CFSFLYYKKY CFYELLRIYR NYCLLNDEEK
SLLSESIYAK IYKMYLSVLN NYYFIMNILL PQISTHIIIH LLSYTFHKDD DVAVVQNDVH
MNCNGNDYRV DNGHYKHSKN KEGGKKDEHN KDNKKDDNCY CKYNNKMSKE EFVINEIIDN
LTVQEKEDID KIYNYYNLDA RLLCKDDPIT ILNEIKFKLI NRKSEKDIYK FLRLEAENSS
SSNNNEGPTN VNTKKGNYEQ VQSSCFPNDI IFNQIKSANS YAFGEKQNSI SEKDEMKVSP
LNEPTSTRSP RKRDREKEAQ EGGNEVDVKE EDVHEVVVRK VDLREVDAPE GGKNANKEDD
ITTNYKHSMT GLLDKDTEQT PSNNVNTKAG EKSLSNRIND NMNFKKCKDE ISVGQEKTNE
LKKVGLPKES DASLVSLSSS SSSYKNKIET DVNKNSKNGE YGENCEKNLE NVINAPACKQ
GYDNRTNGDK TKKKKNKKNK KNNKIKNKSN SSNRESSKGE HIPPGHRISN VYSPSLDEYN
LIQNISKVRS TLRQFVRDWS YEGKHERDNA YELILKSLDK YLPITDTYVP KVLCPGSGLG
RLPYEVAKKG YRSQGNEFSY FMLLASNFIL NYYNEKNSLH IQPYCLNTLN RKGRDDHLKI
IKLPDVNTYN KAVLNTEFSM CAGELIEVYY NEKEQFDGVL TCFFLDTAKN IFMYIRTFAN
ILKPNSLWSN VGPLLYHYAE MPNEMSIELS WDEIKIIISR WFTFLEIKWV DNYYTTNTDS
MMQVQYHCVF FNALRNDVPV DD
//
