ID A0A1A8W0C8_PLAMA Unreviewed; 1048 AA.
AC A0A1A8W0C8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=DNA mismatch repair protein MLH, putative (MLH) {ECO:0000313|EMBL:SBS85401.1};
GN ORFNames=PMALA_012590 {ECO:0000313|EMBL:SBS85401.1};
OS Plasmodium malariae.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5858 {ECO:0000313|EMBL:SBS85401.1, ECO:0000313|Proteomes:UP000078597};
RN [1] {ECO:0000313|Proteomes:UP000078597}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Naeem Raeece;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; FLQW01000689; SBS85401.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A8W0C8; -.
DR VEuPathDB; PlasmoDB:PmUG01_09027100; -.
DR OMA; ANYHVKK; -.
DR Proteomes; UP000078597; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 427..547
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 583..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1048 AA; 121584 MW; 4B16E03DBFA2A55D CRC64;
MHYTESENFK LNREAKQESK IFKLNREAKQ ESKIFKLNKE AKQGTNETKN IKQLRGEQFK
MKVWAYNERG IINMKADTTK KKINLSGYSQ DNLKKKLSAH KNFLPANSNN INGDRNNRGN
PSDERRIIKL AEEDINKIAA GEVIIRPCNA LKELIENSLD ANSTSISVHL NKGGLKSLQI
IDNGDGIHKD DLPIVCERFT TSKITNHKDI RNIKTFGFRG EALASISYVS YLTITTKKRN
SPFCYTCTYK DGKPIQKEPT ICSGKDGTII RFDDLFYNMQ TRLKTLNHND EYNRCLEVLQ
KYAIHYPHVS FTCKKWLSNT VDLNTQNMGK GIGGLGGIYV IKNKKKEKFE SIVREEANVV
GTRVHEEGQA SSTRMHEEAE HSIGNYGEEK ITNAAEDYSV FEKKILEEEK YLDENYEKHL
NNVKSVIQKI YGRNISRELN SIFIKENIPT FFKCYGLIST PKYVGKKGTY IFFINDRLIE
SNIIKRTCEN QYANFIPKGN YPWVYLSLRL KYDIVDINVH PTKKEVHFLY QEEIAQLISK
KIENFLKNVY NIRCFGVPTS NLMQTTFNLT SAKGGVKNEP LTSASSSISN MNGNVKGNTT
PNISVSGETT KKAVDTKRVR TDHKQITLTN YFVKKEEHKK NNKEDRSLVV FEDNNEYEVL
KLEAPKPALF NVNVDKHVSN TRYNRKYTCE CDDISSIRKL KKICEEKEKK ELTECLKNSI
YVGAVDSIHS LIQYKEKLLM IKMPLIIKEI TYQSILNRIG RIPPFKFNPP IPLYDLLLVA
VNNYYSGYYE NPDYVHKNME RICNDLEQLF YSYIEMYTDY FSIIIEEGCV VTFPACCGEY
FPGQEFLPLL FLRLATQIDY ENEINCINGI CYLLANFYSK ITLLDDQEWT FQDDLLMIKE
NEMNMLMNKS HEKKEASSTN TENENYLFDN LLGDETVIDV NKHLAVSKNI NLVFEKYFFP
MIQLNNLMRI PHTFSNNGYI IELTSLNQLY KIFERMNNEE IRMKNEDRRM NNARTIQRRK
RHAGSIHLPH DKPIANILLF IEQETNKG
//
