ID   A0A1A8W3F4_PLAMA        Unreviewed;      1008 AA.
AC   A0A1A8W3F4;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Iron hydrogenase large subunit C-terminal domain-containing protein {ECO:0000259|Pfam:PF02906};
GN   ORFNames=PMALA_019110 {ECO:0000313|EMBL:SBS87311.1};
OS   Plasmodium malariae.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5858 {ECO:0000313|EMBL:SBS87311.1, ECO:0000313|Proteomes:UP000078597};
RN   [1] {ECO:0000313|Proteomes:UP000078597}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Naeem Raeece;
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NARF family.
CC       {ECO:0000256|ARBA:ARBA00006596}.
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DR   EMBL; FLQW01001014; SBS87311.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A8W3F4; -.
DR   VEuPathDB; PlasmoDB:PmUG01_11049000; -.
DR   OMA; DTMHSDK; -.
DR   Proteomes; UP000078597; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1780; -; 1.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   PANTHER; PTHR11615:SF258; CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR CG17683-RELATED; 1.
DR   PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   SUPFAM; SSF53920; Fe-only hydrogenase; 2.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          540..817
FT                   /note="Iron hydrogenase large subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02906"
FT   REGION          49..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          378..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          868..910
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..423
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..444
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        871..894
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        895..910
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1008 AA;  116009 MW;  F7C0332BD723E785 CRC64;
     MFSNAIKLEN LNDYYNDAEE CIKPFLYKSR IVNEQDVEKP NLIIINKKNR NIKNKSGRDN
     GRDRGRDEGK DEGKNEGKNE GKDKRRGEIS LTDCLACSGC VTNEETNFLK SQNSIEILNN
     LNKKKINIIS LSLQSLTALS VYYNLPLSVT QDKLCFFFKS LNFDYVYDSS LSELIALNEA
     KKEFADFFFA NNKGLSKGAS PHTLKESSCN ISGRVSGTEK RKEPIGGNRK SPHKNINVKK
     GANRYKYKHN DDNIYNGWLN GKKTYPLICS HCSGSVIYGE KNFDEELLNS FSKVKSSQDI
     QGIILKILHV HNSSIYTFPL LKNCAIQSFF NSYNYTLELI NICRKHFLKN HNLLKSVNIL
     TSQNLLTSQN LLTSQNLSEN NSLSKDDNVS KDHKVSKNHK VSKNHNVSKD HNVSKDHNVS
     KNHNVSKNHN LSKNHNLSKN HNLSKNHNLS KASLENSTWA NDEAAVGGIG NKGICPLSIY
     DINHVYVLYC FDKKLEAHRN NLQEQTSVDK SMTTFLSYFP IYNNALMTNA DGTNVSVKRN
     LYCVDAVLTT VELVELINSM NINFYALPQL RIDNIYTLLK QIDEGKKKFK RSKSSLDKEY
     NILVDKNKTK EQNMNSIEVI TGKEQINVFA TCVYDNKTTK NGNESEYNAD LVKKGPEEQF
     NILTPSSEKT IIEQLQSLYS DINYNYSIRC SNKNNISMGY GEEIFKFVCK NIFHFNIDEN
     NFNVKYQDIV VLSLFENFSC VFRVVLSYGF KSMYNVLRKL REWKGEKEVE NAEGKEEEAK
     VKGKEKMYEM KITYNLQFTG RIDYIELMAC EKGCLFGCAQ NIFSERVHNF PTCSCYNFRI
     FKKIAEQKVI RNFDFLLADC GAAERGKVEE EGEVEVEEEE EEEVEEEEEE EVDMGKEKDE
     RRQKEKQKEK RTKGQLGALC TCGKLKSPPI PENEALYFEK KDKEKIFQRM YDTMHSDKYT
     LYVNSSNCRN DPTVNSFLRY IFSAFNTETF SLFRAIFSSK KKLDVIKW
//