ID   A0A1A8WDK8_PLAMA        Unreviewed;      1034 AA.
AC   A0A1A8WDK8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Aldo-keto reductase, putative {ECO:0000313|EMBL:SCP02847.1};
DE            EC=1.1.1.21 {ECO:0000313|EMBL:SCP02847.1};
DE   SubName: Full=Oxidoreductase aldo/keto reductase domain containing protein {ECO:0000313|EMBL:SBS89839.1};
GN   Name=PmUG01_13049400 {ECO:0000313|EMBL:SCP02847.1};
GN   ORFNames=PMALA_027590 {ECO:0000313|EMBL:SBS89839.1}, PMUG01_13049400
GN   {ECO:0000313|EMBL:SCP02847.1};
OS   Plasmodium malariae.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5858 {ECO:0000313|EMBL:SBS89839.1, ECO:0000313|Proteomes:UP000078597};
RN   [1] {ECO:0000313|EMBL:SBS89839.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lavstsen T., Jespersen J.S.;
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000078597}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Naeem Raeece;
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:SCP02847.1, ECO:0000313|Proteomes:UP000219813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FLQW01001489; SBS89839.1; -; Genomic_DNA.
DR   EMBL; LT594634; SCP02847.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A8WDK8; -.
DR   VEuPathDB; PlasmoDB:PmUG01_13049400; -.
DR   OMA; KTEDFWY; -.
DR   OrthoDB; 254140at2759; -.
DR   Proteomes; UP000078597; Unassembled WGS sequence.
DR   Proteomes; UP000219813; Chromosome 13.
DR   GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43364:SF4; NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN; 1.
DR   PANTHER; PTHR43364; NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:SCP02847.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000219813}.
FT   DOMAIN          388..768
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   REGION          125..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..154
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..263
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1034 AA;  121824 MW;  B1C39B1D72214660 CRC64;
     MKGQTSILLV VIHTFLLFKE YFCLLKKRNY YTSTFTSTFN LTNKSVTKLK SVRKKYSLRN
     TTFIKTFKSR LTKNYSTFCF IWSNILYVTQ KRRVPSTLEK NNKLSILGTP TGGMTSLVIS
     TKAYAKRNSE EKKENKQKEK ASKEGELQKE KENKSQKRRG RRGRSSTIRD SPDGATVSAL
     RAENNIKKRG RKKKKTAQKE EAVQAENEEN MLDEEQKGEE FYYDRAEDNV EKEEGIETKG
     ISKEEEERQK ERERERQKEK EERDKKIEFI KKVEFLLEED EKNHQLYEER PDISKLRFGE
     KPPPESQDLM NAILSSVHKN EKLEERETID NTDKSEQRSS LKYKHLFYEL LRISNSNSFK
     THKIYTHKDL IYGMKYRKLG ESNLCVSEIC IGTSMYENEN FISKDDVNVL LNMAFYEYGI
     NFFDICEYDP FPHDPDSYKK SKNVNMNLFL KDKKRENIVI NLRMCSSRNV EKSAHGDYYL
     SWIMEGFKDD TPSFYNIEQR LDKILKNLNT NYVDILTIDL PERYIPNSVN GEDTYVWGYE
     NLNLENKKVI SIEEQFEILE KLVLKGKVRH IAVSNESVWG IYEWCNISKK KKKKNMKILC
     VQNLYNLLHR NEVESSGMVE MILKENYNVP LVPYGLLAGG ILTGKYLDPE RYHTIGPETL
     LGDDQLDHDL DDSRGNKAED YGYLSYGPRN GRCNKYPHLY KSHRCVWAQD ATAEYMKIAR
     SHAMTLSQLS LSFVYSRPFV ASSIIGPRTL GQLKDSVLAL NYPMYQHTEY DIHEIFLRYR
     GCTMDGNTIL NSLKDPNKTS QNAFYKTANI PIFSGGSYWN NYPLPFLPKR YAYTDLKEEH
     DRIRSTFGLN DEPNDSNFIS SRIWIEREKR KGEYFALKES ILFEWDKYKV RKGIITELSN
     TEKTLYDTRD FHFYFKNNTI SVTPTDDEIR EFYENKEKVK KVISQAINDH QELYQYQDQI
     GQDMPDIFNN LDIDLIYKQL LNRHNINPLD KMELDYIYQY IKLTPSEIKT ESFWYIYKYN
     PFGTSFGFRT GTEP
//