ID A0A1A8WZH6_PLAMA Unreviewed; 414 AA.
AC A0A1A8WZH6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=5-formyltetrahydrofolate cyclo-ligase {ECO:0000256|ARBA:ARBA00038966};
DE EC=6.3.3.2 {ECO:0000256|ARBA:ARBA00038966};
GN ORFNames=PMALA_057240 {ECO:0000313|EMBL:SBS96841.1};
OS Plasmodium malariae.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5858 {ECO:0000313|EMBL:SBS96841.1, ECO:0000313|Proteomes:UP000078597};
RN [1] {ECO:0000313|Proteomes:UP000078597}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Naeem Raeece;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-
CC methenyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:10488,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57455,
CC ChEBI:CHEBI:57457, ChEBI:CHEBI:456216; EC=6.3.3.2;
CC Evidence={ECO:0000256|ARBA:ARBA00036539};
CC -!- SIMILARITY: Belongs to the 5-formyltetrahydrofolate cyclo-ligase
CC family. {ECO:0000256|ARBA:ARBA00010638}.
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DR EMBL; FLQW01004391; SBS96841.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A8WZH6; -.
DR VEuPathDB; PlasmoDB:PmUG01_14078200; -.
DR OMA; NFNMCIY; -.
DR Proteomes; UP000078597; Unassembled WGS sequence.
DR Gene3D; 3.40.50.10420; NagB/RpiA/CoA transferase-like; 1.
DR InterPro; IPR002698; FTHF_cligase.
DR InterPro; IPR024185; FTHF_cligase-like_sf.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR23407:SF1; 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE; 1.
DR PANTHER; PTHR23407; ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE; 1.
DR Pfam; PF01812; 5-FTHF_cyc-lig; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
SQ SEQUENCE 414 AA; 49588 MW; DFD7123ACEC53C7E CRC64;
MNMLCSDDYK NSITTIDLND CFKNCGNSTS NNSYTNGTIS HSNNNRIIKC IVRENAKKIR
EIVFKHWITQ KKDAFSQCAY TAETNFDEET KQSRLSRSTS GCTCGCKDVE SNERTFYIDY
LYTQLIRHMY IILSTLNVEK KEKGGEFNFS KIYSYTYNYK QIETRDAKEY LRYYGIHDFD
QNFSFFTYYN ACSSKNHGIK IEKDDKDKWD KTNDKKSNFN MCIYLPTKKE VDILFIIEKL
YDFFYFDLYV PITTKENDLI FFPFDLANNL LVKHEFNIYV PFLYIYFNSQ VKKEKRTFHL
NSFNIVTDTL SYFTFEEKKT IFFIPLIAYN KYGCRVGSGK GYYDRTLKDK QHEEQRKKEQ
MKYQYSSCKE IETKKHIKIC LSFDIFLYDI NFSEHTDITL DYIINEKNIF HFLF
//
