ID   A0A1A8XEF2_9RHOO        Unreviewed;       801 AA.
AC   A0A1A8XEF2;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase NAD-binding {ECO:0000313|EMBL:SBT03550.1};
GN   ORFNames=PROAA_1070014 {ECO:0000313|EMBL:SBT03550.1};
OS   Candidatus Propionivibrio aalborgensis.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales;
OC   Rhodocyclaceae; Propionivibrio.
OX   NCBI_TaxID=1860101 {ECO:0000313|EMBL:SBT03550.1, ECO:0000313|Proteomes:UP000199600};
RN   [1] {ECO:0000313|EMBL:SBT03550.1, ECO:0000313|Proteomes:UP000199600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2 {ECO:0000313|EMBL:SBT03550.1};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; FLQY01000010; SBT03550.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A8XEF2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000199600; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199600}.
FT   DOMAIN          4..185
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          190..292
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   801 AA;  87561 MW;  37C0E71ACB6F1186 CRC64;
     MVRKAAVLGA GVMGAQIAAH LANAEIPVVL FDLPAKVGDP NGIVMRARDT LSRLEPSPLA
     TAERIDYIDI ANYAQHLDRL RECDLVIEAI AEKAELKADL YRRIAPFILP NAIVASNTSG
     ISIKLLSGSF PEAMRERFCG MHFFNPPRYM PLVELISSGR TSPALLDELE SWLVSRLGKS
     VVRALDTPNF VANRVGLFSM LAAMRHAERF ELGFDVVDML TGPLIGRPKS ATYRAADMVG
     LDTLTNVIAT MRRACDGNHS DPWSEYYATP AWLSTLIADG ALGQKTGFGI YRNDGKQIQV
     LDQRIRAYRD CRDSSDEIAP EVMAILKNRS PAGKFAQLRA CNHPQARFLW AVFRDVFHYV
     AFHLADIADN ARDLDLAMRW GYGWAQGPFE TWQSAGWQSI ADAVQADIDA DRAMSTAALP
     AWVFARVEHG GVHRSEGSYS ASGGTIKPPS TLPVYRRQLF PDRVFGEEAN SSVMSGTTIW
     ENEGVRLWTL PEIDNDIAIV SLTSKNHTLG HDVLLGMQEA VARAEADYKG LVIWHEAPFA
     YGANLKEVAG LISGGQFDRI GSYIAEFQKT TMTLKYARVP VVAAVQGMAL GGGCEFLMHC
     AKRVIALESR IGLVEAAVGL IPAGGGCKEF AIRAWQNSAR TGSKEPVDFI LPAFTSIVTS
     RVSGSAMQAR EQGFVLDSDP IEFNAKELPY VALRIARGAA EAGYYPKLSP RNVKVAGRAG
     ITTCEAMFAE MCQGGRFSEH DCFVARCAAT ALCGGDIEAG SLVDEQWLLT VELNVFLELV
     NNQKSQQRIQ HLLDTGKPLR N
//