ID A0A1A8XMZ1_9PROT Unreviewed; 1307 AA.
AC A0A1A8XMZ1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=ACCAA_200075 {ECO:0000313|EMBL:SBT05313.1};
OS Candidatus Accumulibacter aalborgensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Candidatus Accumulibacter.
OX NCBI_TaxID=1860102 {ECO:0000313|EMBL:SBT05313.1, ECO:0000313|Proteomes:UP000199169};
RN [1] {ECO:0000313|EMBL:SBT05313.1, ECO:0000313|Proteomes:UP000199169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3 {ECO:0000313|EMBL:SBT05313.1};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FLQX01000095; SBT05313.1; -; Genomic_DNA.
DR STRING; 1860102.ACCAA_200075; -.
DR Proteomes; UP000199169; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd18774; PDC2_HK_sensor; 1.
DR CDD; cd00156; REC; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 3.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 3.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 3.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SBT05313.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000199169};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SBT05313.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 363..415
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 681..900
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 925..1038
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 1054..1169
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 1192..1307
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 887..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 571..653
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 974
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT MOD_RES 1103
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT MOD_RES 1241
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1307 AA; 139813 MW; AC82FAB619659777 CRC64;
MKLGSKLILQ TVLPAVVAVS VLLGIVTLVT SNALQDAAER SLAAVAEARR EEVHSYLHRM
QQDIVSMGSA PAVIEALGAF SAAFAACGSA ADSQLQQLYT RTGELSGNHR GACQSGYARA
YGQHDAFFRQ RHVTYGWHDM LLVDRQGNVV YSLDKGSDFA TNLLSGPWRQ SGLARAASIA
LHESVSGVPV FSDAERYPPA GNRAGMFLAI PLLEPGSGQP LGALAVRIAF EPLDKLTHFK
AGLGESGEAF LVGTAGWLLT NTFFDKESSV LGRQLKTEAV RRVLAGDEGS DQLADYRGQQ
SFIAWRPLQP FAGALGDQPR WGVIAKIGRD EALASLHSLQ WLMLASGLLI ALAAIVLGVV
FTQRLFGPVL AMRDALTRLA NGERTSIPGG DRRDEIGEMA QAAEKFRELS EGVARDRWLR
EHVAALTTAV SQETHLAGVA EIILALLRRQ LDIPVASFFL RDAGGDYRRA GAQGLARRSQ
CVDRFAPGES LVGQCARDGQ PVVLSPVPGG LTLISTGLAE FPPEELVLYP IRHQDETLAV
VELASTHRLS SDEHAFLAAL VGPLGLHLAN IDAAERNVAL LEESRAQAAI LEQQKAELGQ
KNTEMQALTD EMRAQSIELK AQNEAFRTNQ EELRAQQEEL AHQNQTLEAQ GRQLDFSRQD
AEARARELAQ SNRYKSQFLA NMSHELRTPL NSILILARHL AENTGGHLDG DEVESASVIH
ESGNQLLSLI NDILDLSRIE AGKLEVRAED FPIADLLHYL RRLIEPLAEK KSIGFTIDAG
ASDLGTMRSD RRLLTQVLTN LLSNAVKFTD HGAVRLTVRP VDDDICFEVV DSGIGIAGDQ
IGHIFGAFQQ IDGGTARKYG GSGLGLAISR HLVELLGGAI EVDSTPGSGS RFSVRMPRVT
PATGASGPRP APAAPPATTA LPQGLILVVE DDDRLLPIVV RLIETLGYPV RAVGSGEEAL
AAIAAERPAG VLLDLGLPGV SGMEVLRRIR SAPATTDLPV TIMSGAADSG EAQTLGAAGY
IRKPITRDAV QRAIRGMLDA APPLPSAPAT ARPRVLLVED DEAGSLAVRV LFKDTAIEFS
VVKDGSAGLA ALQATRFDAV ILDLTLPDMS GFEWLERVAT ETPMHPPVIV YSACDLDDAG
LLRLRTHAQA VIAKGRLNGQ TSQRLREEVL LALAAPAREP FAAPPAAARR GALLVVDDDV
RSQSALSKVL RSRGFAVSVA TSGAQALEML AGGQFDALLT DIMMPEMDGF ELIRRLRSGA
AQTMPIIAVT AKAMPADIDL CLAAGATDYL AKPVDIDQLL KLLDKCL
//
