ID A0A1A8YTW8_9APIC Unreviewed; 660 AA.
AC A0A1A8YTW8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=dipeptidyl-peptidase I {ECO:0000256|ARBA:ARBA00012059};
DE EC=3.4.14.1 {ECO:0000256|ARBA:ARBA00012059};
GN ORFNames=POVWA1_025770 {ECO:0000313|EMBL:SBT35098.1};
OS Plasmodium ovale wallikeri.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=864142 {ECO:0000313|EMBL:SBT35098.1, ECO:0000313|Proteomes:UP000078555};
RN [1] {ECO:0000313|Proteomes:UP000078555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Naeem Raeece;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except
CC when Xaa is Arg or Lys, or Yaa or Zaa is Pro.; EC=3.4.14.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000738};
CC -!- COFACTOR:
CC Name=chloride; Xref=ChEBI:CHEBI:17996;
CC Evidence={ECO:0000256|ARBA:ARBA00001923};
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; FLRD01000078; SBT35098.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A8YTW8; -.
DR Proteomes; UP000078555; Unassembled WGS sequence.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.128.80; Cathepsin C, exclusion domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR014882; CathepsinC_exc.
DR InterPro; IPR036496; CathepsinC_exc_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF947; CATHEPSIN O; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08773; CathepsinC_exc; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF75001; Dipeptidyl peptidase I (cathepsin C), exclusion domain; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:SBT35098.1};
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000313|EMBL:SBT35098.1};
KW Protease {ECO:0000313|EMBL:SBT35098.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000078555};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 338..642
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 76055 MW; 831F313C5B288FDB CRC64;
MHYEPTGKCD QIKDDDATDS NGETESDLPV HVELSDLLGK WKIFRTKTSP TLTTCGSSQP
NSNIYNVKIK DYKDYLIKNN YHFVSELYVI LSDDFVSYGD MHDTTGNEHR KNWQVLVVYD
EHKRKIGTWT TICDEGFEIR IGNETYTALM HYEPTGKCDQ IKDDDATDSN GETECYITHF
NKIRYGWIEK QLPSTENSNN LQVYHNFTTG TSIHNVFNAH NLLYNVGNYD PPTYTKKSNA
NFDVNSELYW HKMKHHGKKK PITKMMSVYL KQKYACPCSA DEDVQDEKND GDSDKPVSPT
FLQLGNVTQT DEETNELDLE NFEDTLKSPS RELEINEMPK NFTWGDPFNN NTREYEVINQ
LLCGSCYIAS QMYVFKRRIE IGLTKLLDKK YLNNFDDVLS VQTVLSCSFY DQGCNGGYPF
LVSKLAKLQG IPLNKVFPYS GTNETCPYNV EKGPFSAFTR GDNDNEGMTR SSLREIKAAF
GESRENDMHE NFEYSVNADP EKWYAKDYNY IGGCYGCNQC NGEKIMMNEI YRNGPIVASF
EASQDFYTYQ DGIYFVKDFP HAKKCTIDSK KNKKYVYNVT GWEKVNHAIV LVGWGEEEIN
GKNYKYWIGR NSWGKEWGKD GYFKMIRGVN FSGIESQSLF IEPDFTRGAG KILLDKLRNQ
//
