ID A0A1A8ZQU3_9APIC Unreviewed; 5192 AA.
AC A0A1A8ZQU3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Dynein heavy chain, putative {ECO:0000313|EMBL:SBT46197.1};
GN ORFNames=POVWA2_051480 {ECO:0000313|EMBL:SBT46197.1};
OS Plasmodium ovale wallikeri.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=864142 {ECO:0000313|EMBL:SBT46197.1, ECO:0000313|Proteomes:UP000078550};
RN [1] {ECO:0000313|Proteomes:UP000078550}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Naeem Raeece;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FLRE01000182; SBT46197.1; -; Genomic_DNA.
DR Proteomes; UP000078550; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 2.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF36; DYNEIN HEAVY CHAIN AT 93AB, ISOFORM C; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF07728; AAA_5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 2.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 223..587
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 635..832
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1375..1857
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1999..2292
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2418..2556
FT /note="ATPase dynein-related AAA"
FT /evidence="ECO:0000259|Pfam:PF07728"
FT DOMAIN 3133..3214
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 3344..3602
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3616..3953
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3979..4090
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 4181..4289
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 4593..4707
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4738..4879
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4885..5187
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1777..1799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2663..2719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2840..2904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4144..4170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1265..1321
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3628..3665
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3826..3909
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1777..1794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2663..2680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2681..2695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2849..2869
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2870..2891
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4147..4170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5192 AA; 603721 MW; 1E2241FA92E4A4AD CRC64;
MVIGGDGPNG GSVDYDERAE EVVLGALDYF NIGGCLREEA VNSIKSDEDT IKLLGSFFQN
DDEYLFVFNE KDGIKFYGSI LDLYKRRKSE TFLIIYRTPQ KKVLFLEMNN DAENVVRRFL
EIFFSSFMNK NEEINSSSLL KEMKKKFNNF FLNLRIIYGE IEEKLTLPNL PSEVKEVKEE
NINTVEEYLI HFIKCYHIIL RSFMNYKKKN YDNCCEFLLC LQNKNRDIEF LFNEINKESF
KEIINIILEK KKNSSYKNII ENIKNEIIEH KSEVLDLYTH LKPVVHFLQK LECSKHENVE
EKNVYLLPIV HSLSISIEKS EHLIKNCKFV FNFLSKVLIN SCNQNINTPD IINSIYNCVD
VLKSKLYATL NFLLSFLYLF KFYRAKNAKL QTLQSMHESN VRLYKVSTVQ VVEQSIGRES
HIGESHAEIE EECGFFPPVS RYVYKLNMLI EYLKIYQTYM KLEKIEIPGE KGKKLTEEIH
SISKDFNIIN EAFLNINHEI LNEEENIFIN KYNHFENKVK ELNKRLLCVF VYSFDNDLKK
NIKLLNSFLI LRDIHTIEVE LVRHASLLCQ DLKKEFILVD NLFIKNTTII ENNKKMFLEN
SFEEKEIGND QPEKENGMIM MEQNGKELLP RREDDFEDSL KELNINRNAP LFCEVVNLFT
SLLKRIEQQY FPLRKIMKIL KIKNDKSEEI NTLYRSISEK ISKYISEMSK EWFRETIDVV
NNFLNENIFK IKSGIFYVNF HPYIFMFINN VKNFFLNNLM VNDECLKIYN KANTFKRFIN
ILNNITKKYN NVVMKTLDVE KDLFEEKLVM VKNMLLRGVN ELKWTHENIY EYIESMDKDM
SDVYTNICTL HSNIAYIFNL TKGWLKKPII ERRKKSEDIY NYLNGYKNSM SLLKGRLNED
FKNINSKIKQ SYDALKIKKN NLMWKNYLKF LNNIIMDNLI ELTNYLFNNL YEVMKCTKKD
EQLFCIKINF VDNKLNLDLK LRSKKSFSVT SIFYKWIDDF INLCSSIRRI DIKSGDYINE
ILLSLSVNYN KKKVENFFED TIEKSYEYLQ SFKKYEHVWK RDIQAEFLLF KEKNELILSL
KEELNNFYHL KTYECIHFVS FYSENIVECL INFTKNNISL YTEYLQNFVK DVIYSVNTFY
EDVINNLKEI GVSEFFGKKG EESGKNGILS KDGKSASLSY NNGNNVGFTP NVRSSVVEIH
DIGGGADRDN FGGVEGKDVP KSDKKDVFYN LMRNLRSVKL SKKIIPLIFQ KVKEIMEKLK
ELDIVIKHND VLENVEKNKE KVEIQYNEIK EKIIKYKNKE IKNIKMEIQH FREELSKLKK
HIFQNIPSTP KDIYNSPYEK INDFRKSFQI YKDKQKYLNE LEILFEIDIT IFEELHEIDV
KLRDLKHLWD LVNSIIFFIE EEKKKRWKDI DVNSNIYIID FVLLYIRKNF TELKHFSIYE
YVIKELKKLS SILPLLVDLN NDCIFDRHWN IIINISGSVD SLHSKGGGDP SGSSVAIVGC
ASGGEEGDEG MGSARAPLRA GSQVNKNFKI KYKELTLQEF FDLKLYKHVD AVHDVIEQAK
KEKKIENKIK EINVIWKDMT FEFVRKNTYI QITNMDMILE IVDVHTSEIL FFINQKKYIL
FIQETILNTQ ENLKKIDEVI NIWRKFLSKF ERLQPIYLNS EDIHSQLPQE SKMFFTIENE
YKEIIQSTYE QKNVLQICLN EELFYLLSKF FKNIELCEKA LNDYLDQKKK AFPRFYFLSN
IALLDILSNG KNPLKILPYI NDVFNAIKTI EFDQGGEQAA EKKGEEENQE ERQVHGQAQG
DVLTEGGREY VARGVYSIEN EHLQFLSKLT LKGNVEGYLK DLENHLKVTI RSILENAKIL
AENLDEQNRD ETMIGNYISQ VVCTCNQICV TEEINKCFDE LENGNESAFL DYKKVLIERI
NKLIKMVEKT ENYNTRTKLL SLIILDVHTR DVIISFVKKK ISDSTSFDWQ AQLKYYWIYD
KKINNYTCEI KLCDFKTKYL YEYIGNSGKL VITPLTDKCY ITLTQALNLI LGGAPAGPAG
TGKTETTKDL SKAIGIAIFI FNCSNQMNYF NMSQICIGLS QTGAWGCFDE FNRISIEVLS
VVSTQIKCIF DAIKDKKTIF HFIDDEIVLK KTCGFFITMN PGYAGRTELP ENLKNLFRSC
SMIVPDIKFI CENMLMSFGF IKANKLSYKF VELYQLCKEL LQKSTHYDWG LRAVKVVLIQ
AGNLKRKYSN FDEEVILMKA LKDFNIPKIT HEDIPIFLGL VNDLFPNVNC NVFMEDVTTV
QRNTEKPVTN STKICTSQVQ NCTTFRKEDQ MNGHNSLAGK ENQWVVAGVR GGDSSNISQV
INPSGNDEGM NKMNGEDDLK DNRRLSCVES LQKGKENGIH CFDDAIRVCL KEYNLQIDDN
FISKVKQLKD LMDVRHCVFI LGEDGCGKST VIEMLIKSLN KIEESCLHEI INPKSIESYE
LYGYLTKNNE WVDGALSSIM RKMSRNISPY NENIKHKIIL LDGNIDAEWI ESMNTVMDDN
KVLTLVSNER IPFTKEMHLF FEITNMKYAS PATVSRGGVL YINKGDISYR LFISSWINLL
NNNIAKTEFY YLFNIFYEQN MEMLRKQCKF AFNLSNLDIV KSICSYIDYF LVKYEKYISE
VIKKIENKQN EENSLFGGEI HSGQASIPPQ SSPPRTTQEQ NVERQWKEAE DAKGNSLRVP
RGGSASEQEV SKKNPNLKNL SEGAKGTDGI MVSGEEKNIV NKINYNYEAL KDYYNCFFMN
SYMWVLNNLI IDDKIMNAKN VFSNNIKTNL KVKMGSDYCC NYIYNVYENS WKHLSEYLDE
DVLFLQRLKW NFDEVEGGEK AYQGGGEEMD ELELGEEEEA GEEEDGGEDM SNLADKRASS
GDDVDTGKEK QREKKKKKKK RAASNYVESM LPHKYDEIYI NTIELLRVEK MIKYSLERNK
PILVYGNNGT GKTKCIKNNI NMNIDKFTHT VISINYYTNS FVLQKIIENN VEKRNTRTYG
PPNQKKHIFF LEDLNITAKD NCDTQQTLEF LRQLLTYKLI YDRDNLDEKK YIHDISFIGT
INNNTNKLID KRIQNKFNLI NIDDISMKTF ENVYKVIIKQ HLLKFDDTIK GLLNPIISFS
YDLYSNITEN IAFNLSNLAP HYLFNLNDIH TIFYNVIKYT NPDIYNNAFK FLMIVFHETQ
HAYINKMISD EHIHIFTQLF NRLLVQYFPS FKDDFDKHRA MFDGKSGENC DGGCGISRSS
SSSNGKRIES TNMGGECIDG IQAGQCAQIN ERGDFGGIGG SSGNVGSASN LTNAAYDPSK
NIFTSFISVR NGLDKMYLGV KKFYVLKEVL AEKLNEYNST HVELPLVLFD YAIIQICKIC
RILDFNISHL MLIGFGGSGK QSLMKLSIFI NSLNLISISI NNNYDVNNFK TDLQEFHLKC
AIKPGNVHVL LLKEKDVLDS FLPYINDLTS TGLCNDLFSK DEYLGIFSSI RNQIKYLNIG
ESNEDVFNYY ISKIKKNFKI AITHSPISNM YRDRLIKFPS FLSNFSFIYF LPWPYEALVN
VSNRFLNDVE INEDLKKSIC EHMAYVHTTT NDINKMYLEQ KNRYNYVIPK TFLEYIYFYK
NLLNVKTVEI EKSVQRLNKG LLALTSTREN VQVLKKEIEI KIINIEEKKI EVNEILNKVK
EATEVTNKEQ EIVNEEKKKT EIFTREAIEI QLKADKELSE ALPIMNKAKD AVNCITKSAI
QELKSLQNPP KECLDVTHAV LIALKEIKNY SWKFAQKIMN NPTQFLSKLQ KFDAENMDEE
TVHLLTPFIE KKFFNYEMMK TKSSACAYLA LWLVNIVKYN EIYKKVKPLM DKLQEATSNK
NNAQEKLDQL ENKVRELTES VEKLRTKMNE VNEEKNNVIK IYNESKDKLN RAENLVNMLS
DEYSRWSDEI AIIISNKKFI YGDCLLLSSF ITYLGVFSSS FRIKLWKDLW LEHIKRSNIL
INNITSPIDI MVQDIQIATW KNEKLPEDKI SIENALIVST CYRWPLLIDP QLQGLKWLKA
KGGNNITCLQ FNCENFIRKV KNVITKGGYL IIENITEEID NVVDGLLNRE FIKRGNDTYV
KIDGEEMQFN YPNAISRIEK IKSFFENGSN GASSGSGASG SGARGSAINQ DKFSGELYEG
DKSLHQKAHS QNGQNGHNGH NGHNGQNINK SLSNESLAKV NFFNLILQTK LSNPHFKPEV
NSQCTLINFS VTCEGLEEQI LAIIVNIEKP ELEKQKQILV KNRNEYKIIL NNLEDEILYQ
LSTVDSTTII DNIALINSLR TTKDTSINIQ RQVSDSITTE NEINKTRELY RTLANEASIV
YFILILMHNI NYMYQYSLDS FISLLLKSIE AVHTAGSSGK EENVLGGKEP GGAAAERQEN
SLYEGKICFG ERNEKGSSEM VGDSAYDEHM ERLIISFRKT IYSWISRGLL EKDKLLFNCI
FVFKLLEKKK IYDRDFSMDY LNFFLKPPRG KSVGENPLKE WLSDECWENI QLLSKFKEFE
NLSNNIHIDA QHKFKQWCSE IQPEICKLPL EWKKLDNYSF KKLLIVRSLR PDRITVTLER
YIKNVLPKSE EIMEKKNSFV DTLESSYNFM INSTPILFIL TPGSDFIKYV ELLGKKYKFY
LNQNLHVVSL GQGQESIALS KLELSHKEGH WIVLENIHLM AKFNLILENV IDKYSTEGSH
PNFRCFLTSE ITTNIPISIL ERSIKLTNEA PTGFKENLKR AFTFFSPDDY EEKDLRTKNI
LFSLCYFHSI IVERAKFGAE GFNIKYPFSL SDLRDSAKVL FNYLDNQNSI KVPWNDLKYI
FGEIMYGGHI VNDKDMLVCK TYLNYFMKEQ SLEGMELIPF SKNVQLFSPN NYAYDKILKY
IDTQIVVESS ILYGLNQHAE MNFRTNESIK LLKNILTLKL KETSTFVEEL STGETIEKKT
SLILLEILSE IDNVFFNVEE LTKSIPDDQI TPLQYFLFQE CTLMNGLTNI MKNSLKELHL
AIKGEINMNS KIELLMHSLY KDQLPELWKN NSYSSNRNLS SWVNNLKERI TFLSDWFNDP
LLTPKVFNVS LLFNPNSFFS AIKQILSRNE KCELDKIIMQ IEVTNKSLNH IHSYPKEGAY
IYGLYLDGAN YDVEKNTLCD SSSKQKYFLM PVIHCKPVVS MGKIDTDVYE CPVYKTLSRG
PTYVTSIKLK TKENPEKWIL AGVALILDIA DD
//
