ID A0A1A9BCN4_9ACTN Unreviewed; 3119 AA.
AC A0A1A9BCN4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Acyl transferase domain-containing protein {ECO:0000313|EMBL:SBT66851.1};
GN ORFNames=GA0070622_3882 {ECO:0000313|EMBL:SBT66851.1};
OS Micromonospora sediminicola.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=946078 {ECO:0000313|EMBL:SBT66851.1, ECO:0000313|Proteomes:UP000199558};
RN [1] {ECO:0000313|EMBL:SBT66851.1, ECO:0000313|Proteomes:UP000199558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45794 {ECO:0000313|EMBL:SBT66851.1,
RC ECO:0000313|Proteomes:UP000199558};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FLRH01000003; SBT66851.1; -; Genomic_DNA.
DR STRING; 946078.GA0070622_3882; -.
DR OrthoDB; 5476359at2; -.
DR Proteomes; UP000199558; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 2.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR036299; Polyketide_synth_docking_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SBT66851.1}.
FT DOMAIN 33..459
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1430..1505
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1522..1947
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2964..3039
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1400..1423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3119 AA; 324013 MW; CCE2DDCE9A81BA21 CRC64;
MANEDKLRDY LKRVMADLHD TRRRLSEAQS QELEPVAIVA MSCRLPGGVR DPRDLWELLR
DGRDAVAPFP DDRGWDLDRL YHPDPDHPGT SYAREGGFLD GAGDFDAAFF GISPREALTM
DPQQRLLLET AWEAVESAGV DPATLRGSRT GVFVGTNGQD YGTLLMMSPD ADEGHSMTGG
AAAVASGRVS YTLGLEGPAV SIDTACSSSL VALHLAAQAL RAGECELALA GGVTVMATPG
LYIGSSRQRA LSPDGRCRSF AASADGAGFS EGVGWLLVER LSDARRNGHP VLAVLRGSAV
NQDGASNGLT APNGPSQQRV ISQALTAARL ATADVDVIEA HGTGTNLGDP IEAQALLATY
GQDRGDAGPA LLGSVKSNIG HAQAAAGVAG VIKMVLAIRH GLVPATLHVD EPSPHIDWSA
GALELVTEAR PWPDRDRPRR AAVSSFGISG TNAHVIVEQA PDEPAPAADP PTSGLVAADV
TAWPLAARTR AALGGQAARL AAHLRAAPAD PAAVAWSLAT TRTAFEQRAT VVGASAEDLL
SGLDALAAGT PSPTVVTGMA SRTAGAVFVF PGQGAQSARM AAGLVGRTPV FDAALADCQA
ALAPFLDVDL PSVLTGDDES WLERVEVVQP VLWAVGVALA AVWRHVGVTP QVVIGHSQGE
IGAACVAGIL SLEDAAKTVA LRSRALSVLR GTGTMASVDL PADEVTTRLN GFAGVGIAAV
NGPSTVVVSG PPQAVADFVD ACQADEIRAR LIPVDYASHS AAVEDVAQQL RADLADITPQ
PGHTRMVSTL TGDWADPVSM DAHYWYDNLR QTVRFDTAVR TAIGAGHTAF VEISPHPVLA
MPVTAILDDT ATTGHVLSTL RRGDDDPTRL LTNLATAHAV GLPVDLTRVL PETATVDLPT
YAFDHQRYWP APPRFVTDRD GEPDPDRWHY RITWTPRPDL PLTRLGGSWL LPVPADLTDA
PLVTDVLAAL GNVGADAVPV PVDPADDPAA LAERLRAALP DSGPAAVLSL LGLDGRPHPD
HPATTLGVTG TAHLVQALGA LGVEAPLWCA TRRAVTTGDT DPAPEPAAAA VWGLGRAVAL
EHPARWRGLV DLPDRLDARA AALLGAVLGA DDGEDQIAVR DTGVHVRRLT RLTHPADHDL
RLRDTVLITG GTGGLGGHLA RWAARAGAAH VLLASRRGPD APGAGDLTAE LTDLGVRVTV
ARCDVTDRDQ LAALLADLPD DAPLRAVLHT AAVLDDGIVD TVTPARLHTV AAPKSAAADH
LDALTRDHEL DAFVLFSSVA GTTGNAGQGA YGAANAHLDA LAHRRRADGL PALAVAWGAW
DGAGLPADNE RAQQRLRRGG MVAMDPELAV AALTRALGGD DAATMVADVD WTRFAPAFTL
VRPSPLLGDL PEVHEALRPP QTPAATEPAD EPGSALARQL AGRSAAERTE TLRDLVRQCA
AGALGYGSAD DVGVNRPFRD LGLDSLTAVD LRNLLATATD LRLPATLAFD YPNPAVLAGH
LDELLTGAGA AVTGPAAVAT PDEPLAVVAM SCRFPGGADD PERLWQLLAA GGDAIGDFPT
DRGWDLDRLF DADPAVEGTS YARQGGFLPD VADFDPGFFG ISPREALAMD PQQRLLLETS
WEAIERAGID PQALRGSPTG VFVGTNYQDY RNLMLTAEGA EGHLMTGNAG SVLSGRVSYT
LGLEGPAVSV DTACSSSLVA LHWAGQALRA AECSLALVAG VTVMATPGVF VGFSRQRGLA
PDSRVKAFAA GADGTSWGEG VGVLLVERLS DARRNGHPVL AVIRGSAVNQ DGASNGLTAP
NGPAQQRVIR AALANARLDA GDVDAVEAHG TGTRLGDPIE AQALLATYGQ GRPEDRPLLL
GSIKSNIGHT QAAAGVAGVI KMILALRHGY LPPTLHVDAP SDQVDWSTGA VDLLTEGRPW
PLTGRPRRAA VSSFGISGTN AHTILEQAPE PPVPAGEPAY PPVVPVLLSA RTAGSLAAQA
QPWADRLTGP QAPPLVDVGW TSAVSRAALE HRAVVLATDR RTLRAGLRAL RRGDDSPALV
TGAVTARPRV AYLFSGQGAQ RPGMGRELAA AYPAYADALT EVCAALDPHL SRPLRPLLDA
EPGTPEAALL DRTEFTQPAL FAVEVALFRL LTAWGLRPDA VAGHSIGEFA AAYAAGVLTL
ADAAELVATR GRLMQALPDG GAMLAVAAGE DAVRPTLGAG VALAAVNGPA AVVVAGETDA
VDRVAAEWTA RGVRTRKLAV SHAFHSPLME PVLDELAALA ARLPHHAPTV PLVSTVTGTP
VDVAAVGAPG YWARHARDTV RFADAVTALR AHGCTAYLEV GPDGVLTPAA QSVLADAGPV
PPVLPTLRRD RPEPLTLLRA VAALHVHGVA PDWPALYAGA DPQPADLPTH VFDRQRYWPQ
PPAWLTAPAD ADTAVERRFW AAVDAEDLDG LLTELDVAPE QPFDAVLPAL SAWRRRGRER
SLVDGSRYRV RWEPVDVGAG TPPAGRWLVL LPADRATDPD LTALAGALGP AATTATVDTA
AAPDELATRL ADLVAAATGD GPSHVLSLLG LDETSHTDHP ALPRGLAATV HLLQALTDLD
APARLWCATR GAVGVGDGDT PDRPRQAALW GLGRVAALEQ PARWAGLVDL PATVDDDTAR
RTAALLATTT EDQVAVRADG AYARRLDTAV TDGEPTPWQP RGTVLITGGT GALGGHVARW
AAGAGAERIV LTSRRGADTP GADALLAELA ETGVECRVAR CDAADRSAMT DLVAELRRDG
PPLRAVVHAA GVSEVVPLAE TTLEDLAYVI GPKLAGAELL DELLDGVELD AFVLFSSIAA
TWGSGGQGAY AAGNAHLDAL AQRRRARGLP ATSVAWGPWT ESGMFDDDAP EQLRRRGLRV
LPPGPAMAGL RHALAAGDTC VTVADVDWAT FHPLFTALRP SPLLADLPAV RALAAAPEPA
ANAGPEGADR LAELRALPAA DRRDALLDLV RTDAAKVLGH PSVDAVDPER GFLDLGFDSL
TAVELRNLLT AATGRELPTT VVFDYPTPAG LADHLDAELF PDGGDPAAGD PADEETVRRV
LAAIPLDRLR QAGLLDPLLR LGQDTAAPAP DATPDAPAAE IRDLDVAGLV RMALEGSDS
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