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Database: UniProt
Entry: A0A1A9BCY8_9ACTN
LinkDB: A0A1A9BCY8_9ACTN
Original site: A0A1A9BCY8_9ACTN 
ID   A0A1A9BCY8_9ACTN        Unreviewed;      4711 AA.
AC   A0A1A9BCY8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Acyl transferase domain-containing protein {ECO:0000313|EMBL:SBT66854.1};
GN   ORFNames=GA0070622_3889 {ECO:0000313|EMBL:SBT66854.1};
OS   Micromonospora sediminicola.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=946078 {ECO:0000313|EMBL:SBT66854.1, ECO:0000313|Proteomes:UP000199558};
RN   [1] {ECO:0000313|EMBL:SBT66854.1, ECO:0000313|Proteomes:UP000199558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45794 {ECO:0000313|EMBL:SBT66854.1,
RC   ECO:0000313|Proteomes:UP000199558};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FLRH01000003; SBT66854.1; -; Genomic_DNA.
DR   STRING; 946078.GA0070622_3889; -.
DR   OrthoDB; 5476359at2; -.
DR   Proteomes; UP000199558; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd08952; KR_1_SDR_x; 3.
DR   CDD; cd00833; PKS; 3.
DR   Gene3D; 3.30.70.3290; -; 3.
DR   Gene3D; 3.40.47.10; -; 3.
DR   Gene3D; 6.10.140.1830; -; 3.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 3.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 3.
DR   Pfam; PF00109; ketoacyl-synt; 3.
DR   Pfam; PF02801; Ketoacyl-synt_C; 3.
DR   Pfam; PF08659; KR; 3.
DR   Pfam; PF18369; PKS_DE; 3.
DR   Pfam; PF00550; PP-binding; 3.
DR   SMART; SM00827; PKS_AT; 3.
DR   SMART; SM00822; PKS_KR; 3.
DR   SMART; SM00825; PKS_KS; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   SMART; SM01294; PKS_PP_betabranch; 3.
DR   SUPFAM; SSF47336; ACP-like; 3.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR   SUPFAM; SSF53901; Thiolase-like; 3.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00606; KS3_1; 3.
DR   PROSITE; PS52004; KS3_2; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SBT66854.1}.
FT   DOMAIN          34..460
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1451..1525
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1542..1968
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          2993..3068
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3086..3511
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          4555..4630
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   4711 AA;  488990 MW;  506C03E9E510C26F CRC64;
     MNSEDEKYVE YLKRTTSELR RTRRRLRALE ARDTEPVAIV AMTCRYPGGV GSPEQLWDLV
     RDGGDGIGPF PADRGWDLDR LFHPDPDHPG TSYVREGGFV YDAGDFDADL FGISPREAVA
     MDPQQRLLLE ATWEAFERAG LPLPAVRGSR TGVFVGAAAH GYDAILAQAG QDGEGHSLTG
     NSTSIVSGRI AYTLGLEGPA VTIDTACSSS SVAIHLAVQA LRNADCELAL AGGVTVMPTP
     AVFVGFSRQR GLAADGRCKP FAAAADGTGW SEGVGMLLLA RLSDAQRHGY PVLAVIRGSA
     VNQDGASNGL SAPHGPSQVR VIRQALANAR LTPEQVDVVE AHGTGTTLGD PIEAQALLAT
     YGQDRGDAPP VLLGSVKSNL GHTQAAAGVA GVIKMVLALR HGVVPPTLHV DRPSPHIDWD
     AGAVALATEA TPWPAVDRPR RAAVSSFGVS GTNAHTILEQ APEPEPAEDE PAPVDRPVVP
     VLLSARSPEA LAAQAGRWAA WLDADPDVRP LDVAYSSVVS RSVLDHRAVL AAAGRDDLVA
     GLRALAAGEP AGTVVTGTGT PRGQLAVLFS GQGAQRAGMG RELYAAFPVF AAALDEVCGH
     LDRALPRPLR EVLFAADGTD DAALLDRTAF TQAGLFAVEV ALFRLVESFG VTPDLVGGHS
     IGEVTAAHVA GVLSLEHAAA LVAARGRLMQ ALPAGGAMLA VAATEADVRA TLTDPDAPID
     VAAVNGPAAV VLSGAADEID LAERRWRDRG VRTRRLTVSH AFHSPLMAPV LDRFRAVLDR
     LTFAAPTLPV VSNLTGDLAD PDEIRTPEHW VRHVREAVRH ADGVRALRAA GVDTFLEIGP
     RAVLTPLTAD ILPDEPVRAV AVQRGDRAEP EALLAALADL HVHGHPVAWP TWFTGAGARR
     TDLPTYAFHR HRYWAGDGGV PPATATEGVD GDFWAAVERG DLPAVASHLA VQDDPEAVAA
     LAPAVPVLSS WRRARHRDAT LDGWSYRVVW EPVHPSPAPA LTGRWLVVAL DDPAPWAAPL
     ARAGADVDLL TVPADADRAA LADLLRDHPE PGWRGVLCVL PAPDAPRPDA PAVPAGTALL
     LTLTQALADT GRSGRLWCLT RGAVTVGGGE PLTDPYAATA WGLGRVVALE QPDRWGGLVD
     LPAGDTPDRA SADALLTVLA DGGHDEVAVR AHGTFGRRLV PAAPPAGPGW RPTGTVLVTG
     GTGALGRQVC RWLLDAGATD VVLASRRGPD APGVADLVAE LPGARAVRCD VTDSAAVAAL
     VADLPALTAV VHAAGAVDDG ILEGLDLPRT QAVLDAKVRA ARALHDATAG RDLDAFVLFS
     SLAGVIGSAG QGNYAAANAF VDAFATWRHD LGLPATAVAW GAWAAEGMAA ASADLTARLV
     RGGVHPLPAE QAAAALGRVV GAGPALTVAD VDWGRLAATR GRPAPLLTGL PGVPAGPAVV
     TPAVVVGRSL PQLTELVRAQ VALVLGHPAG RPLPDRTFRD LGFDSLTAVE LRNRLAAETG
     ATLPATLVFD HPTVAELAAH LHGLTADPTG GAVVAADVDR HREPVAIVAM SCRFPGGVAT
     PEQLWELVAG GTDALSTMPQ ERGWNVAELY HPDPEHLGTS YVCEGGFLTG AGEFDPAFFG
     ISPREAVAMD PQQRLLLETA WEAFERARLD PAGLRGSRTG VYVGTNGQDY GSLLLAAGDG
     DENYLATGVS ASVISGRLAY TFGLHGPAVT VDTACSASLV ALHLAAQALQ AGECDLALAG
     GATVMATPGI FVGFSRQRGL AADGRCKPFA GAADGTGWGE GVGLLVLQRL SDARRDGNPV
     LAVVRGSAVN SDGASNGLTA PNGPAQQRVI RQALANAGLA PDQVDAVEAH GTGTTLGDPI
     EAQALIATYG RDRDTDRPLW LGSVKSNLGH TQAAAGVAGV IKMVLAMRAG VLPPTLHVDE
     PTPHVDWSAG TVALLTEARP WPAGDRPRRA AVSSFGISGT NVHTVLEQAP PEEPAPRDAV
     PAGELPWTLS GRGTAALAAR ARDLRAHLDA VPDAALPDLA WSLATTRTAH EHRAVVLAAG
     RDDLAAALDA LAAGRPAPHT VTRPPGTGGD VVFVFPGQGS QWTGMAADLL ATAPVFAETF
     TACAQALRPH LDWSPVDVIR GAPDAPSLER VDVVQPTLFA VGVSLAALWR SYGVHPSAVV
     GHSQGEIAAA YVAGGLSLDD AAAVVALRSR VIAEIAGDGG MVSVATTADE ATETIGRWDG
     RVALAAVNGP TSVVVSGDAA ALDELIAHYQ GRDVRVRRVP VDYASHSAHV EPLRERLRDL
     LAGLRPRTGD IRFRSTVTGD WTDTAGLDAD YWYRNLRQTV GFDAAIRDLA ATGHQTFVEV
     SAHPVLTMAM QESVEAAAAD PTAVTVTGTL RRDEGDLARF HRALAEAYAG GVAVDWRPAF
     AGLAARRLDL PTYPFQRQPY WPRPAAVPVA AAPVEPDEVD ARFWAAVEAE DPAAVGAELA
     DTADVPADAL AALLPALAAW RRRHRDQATV DSWRYRDGWL PVAPDAADRP TLDGDWWLVT
     GPGDLGVDAA DVVADALRRH GATVVPLALT GERTDRDALT ARLRDRHADA PPAAVVSLLA
     LDETPLPAHR HVPAGYAGTV TLTQALGDAG IRAPLWTLTR GAVSTGPTDP LPHPTQQLAW
     GFGRIAALEH PDRWGGLVDL PDTVDDRTAT RLARVLAGAD GEDQVALRPT GAYGRRLLRA
     PLGDTPAPRD WRPTGTALVT GGTGALGGHV ARWLAAHGAD HLVLLSRRGR DGDGVDELEA
     ELTALGARVT VAACDAADRD ALAAVLAGLP AEHPLTTVVH TAAVLDDAVI GALTLDRIDH
     ALGAKVTAAV NLHELTRDHD LDAFVLFSAM AGTVGSSGVG NYAPGNAYLN ALAEHRRGLG
     LPATSIAWGA WGGGGMADGE FGRMLHRHGA PEMHPRLAIA ALHQALAHDE TYLTVSNIAW
     DRFRVALTAT RPAPLIAEIP EARQLAADRE PDETAEAAPA GAFARMASDE RREALLDLVR
     DQAATVLKYA GGEAVDPHHA FRDLGFDSVT AVELRNRLAT ATGLRLPVTL VFDYPTATVL
     ARHLHTELGG VAETGPAAGP TPLADDEPVA IVAMSCRFPG GVTDPERFWQ LLHAGRDAVS
     DLPGDRGWDL DGLYDPDPYS AGTSYVRTGA FLYDVADFDA GFFGISPREA VAMDPQQRLL
     LETSWEAIER AGVDPGGLRG SRTGVFVGTN GQDYGALLMV SADEVEGFAS TGNAASVVSG
     RVAYVLGLEG PAVSVDTACS SSLVALHLAA AALQRGECDL ALAGGVTVMA TPGLFVEFSR
     QRGLAPDGRC KAFAAAADGT GWGEGAGMLL VERLSDARRN GHPILAVLRG SAVNQDGASN
     GLTAPNGPSQ QRVIRAALAA ARLSPADVDV VEAHGTGTTL GDPIEAQALI ATYGQGRADV
     EPLLLGSVKS NIGHTQAAAG VAGVIKMVLA MRAGVVPPTL HVDAPSPHID WSAGAVELVT
     ENRAWPAAGP RRAAVSSFGI SGTNAHVILE LPDETPADAA RPGPPAGADT ARSGLLDGAL
     AWPVSARTRD GVARQAGRLA RHLRGTSADP AVIAWSLATT RSAFDHRAAV VGSSAKDLLS
     GLDALAAGTP SPAVVTGTVA GRGAGPVFVF PGQGAQSARM AAGLVGRTPV FDATLADCQA
     ALSPFLDVDL PSVLTGDDES WLDRVEVVQP VLWAVGVALA AVWRHVGVSP QAVIGHSQGE
     IGAACVAGIL SLEDAARTVA LRSRALAALR GTGTMASVDL PADEVTARLE ADRATDGAVG
     PDAVAPGDTD GAGRFSGVGI AAVNGPSTVV VSGPPQAVAD FVAACQADEV RARLIPVDYA
     SHSAAVEEVA QRLRTDLADV APQPGHIRLV STLTGDWVDP ASMTADYWYD NLRRTVRFDT
     AVRTAVGAGH STFVEISPHP VLAMPVTAIL DDTATTGHVL STLRRGDDDP TRLLTNLATA
     HAVGLPVDLT RVLPETTTVD LPTYAFDRER YWPRTRTVDT ADAPTGADAA FWAAVDNEDL
     AALADLTAQD ATESLDRLGA ALPLLADWRR RQRDRSTLDD LRYRAVWQPY AGVPVAFLTG
     AWWVVADPDG IAEAETAVAE LTRRGADARL VLLPEDATDR AAVAARLTAA GAGPVDGVLS
     LLALADTPAD APVPPFLARS LALLQALGDL DVPAPLWCVT RGAAGTTRDG GVGRPEQALL
     WGLGRVAALE HPQRWGGLVD VPATLDDHGW DLLCAALSGP DGEDQLAVDG VTLLVRRLVR
     APGGGADPAD GHPGTTLVTG GTGALGGQVA RWFADRGAAH LLLVSRRGAD APGAADLVRD
     LTDRGARVTV AACDVADRAA LAKLLDDVPA DAPLTTVVHA AGVLDDGVLD GLTADRIADV
     LRPKALGALH LHELTAEKDL RAFVLFSALP GQLGAAGQGS YAAANAYLDA LAEQRHRQGL
     PATSVAWGPW ATGGMADADP AVAERRRRSG VTRLDADLAL TALAGCLTGR EPVTLIAGVD
     WARYVPGFTA VRPSPLLTGI PEARRAAAER AEEGGPTADS LAALLAGQTD AERRRTVLDL
     VRGQAAAVLG HASDAAVEPD RAFRDLGFDS LTAVELRNRL TAATGVRLPA TVVFDYPTAA
     LLAEYVRAAV VDGGVAAATP VFGELERLEA ALAGAAPDRG ARLRITERLR TLLASLNEVD
     APADGDGVAG KLQDATPDEV FDFIDRELGV S
//
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