ID A0A1A9BCY8_9ACTN Unreviewed; 4711 AA.
AC A0A1A9BCY8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Acyl transferase domain-containing protein {ECO:0000313|EMBL:SBT66854.1};
GN ORFNames=GA0070622_3889 {ECO:0000313|EMBL:SBT66854.1};
OS Micromonospora sediminicola.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=946078 {ECO:0000313|EMBL:SBT66854.1, ECO:0000313|Proteomes:UP000199558};
RN [1] {ECO:0000313|EMBL:SBT66854.1, ECO:0000313|Proteomes:UP000199558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45794 {ECO:0000313|EMBL:SBT66854.1,
RC ECO:0000313|Proteomes:UP000199558};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FLRH01000003; SBT66854.1; -; Genomic_DNA.
DR STRING; 946078.GA0070622_3889; -.
DR OrthoDB; 5476359at2; -.
DR Proteomes; UP000199558; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 3.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 6.10.140.1830; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF18369; PKS_DE; 3.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SBT66854.1}.
FT DOMAIN 34..460
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1451..1525
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1542..1968
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2993..3068
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3086..3511
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4555..4630
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4711 AA; 488990 MW; 506C03E9E510C26F CRC64;
MNSEDEKYVE YLKRTTSELR RTRRRLRALE ARDTEPVAIV AMTCRYPGGV GSPEQLWDLV
RDGGDGIGPF PADRGWDLDR LFHPDPDHPG TSYVREGGFV YDAGDFDADL FGISPREAVA
MDPQQRLLLE ATWEAFERAG LPLPAVRGSR TGVFVGAAAH GYDAILAQAG QDGEGHSLTG
NSTSIVSGRI AYTLGLEGPA VTIDTACSSS SVAIHLAVQA LRNADCELAL AGGVTVMPTP
AVFVGFSRQR GLAADGRCKP FAAAADGTGW SEGVGMLLLA RLSDAQRHGY PVLAVIRGSA
VNQDGASNGL SAPHGPSQVR VIRQALANAR LTPEQVDVVE AHGTGTTLGD PIEAQALLAT
YGQDRGDAPP VLLGSVKSNL GHTQAAAGVA GVIKMVLALR HGVVPPTLHV DRPSPHIDWD
AGAVALATEA TPWPAVDRPR RAAVSSFGVS GTNAHTILEQ APEPEPAEDE PAPVDRPVVP
VLLSARSPEA LAAQAGRWAA WLDADPDVRP LDVAYSSVVS RSVLDHRAVL AAAGRDDLVA
GLRALAAGEP AGTVVTGTGT PRGQLAVLFS GQGAQRAGMG RELYAAFPVF AAALDEVCGH
LDRALPRPLR EVLFAADGTD DAALLDRTAF TQAGLFAVEV ALFRLVESFG VTPDLVGGHS
IGEVTAAHVA GVLSLEHAAA LVAARGRLMQ ALPAGGAMLA VAATEADVRA TLTDPDAPID
VAAVNGPAAV VLSGAADEID LAERRWRDRG VRTRRLTVSH AFHSPLMAPV LDRFRAVLDR
LTFAAPTLPV VSNLTGDLAD PDEIRTPEHW VRHVREAVRH ADGVRALRAA GVDTFLEIGP
RAVLTPLTAD ILPDEPVRAV AVQRGDRAEP EALLAALADL HVHGHPVAWP TWFTGAGARR
TDLPTYAFHR HRYWAGDGGV PPATATEGVD GDFWAAVERG DLPAVASHLA VQDDPEAVAA
LAPAVPVLSS WRRARHRDAT LDGWSYRVVW EPVHPSPAPA LTGRWLVVAL DDPAPWAAPL
ARAGADVDLL TVPADADRAA LADLLRDHPE PGWRGVLCVL PAPDAPRPDA PAVPAGTALL
LTLTQALADT GRSGRLWCLT RGAVTVGGGE PLTDPYAATA WGLGRVVALE QPDRWGGLVD
LPAGDTPDRA SADALLTVLA DGGHDEVAVR AHGTFGRRLV PAAPPAGPGW RPTGTVLVTG
GTGALGRQVC RWLLDAGATD VVLASRRGPD APGVADLVAE LPGARAVRCD VTDSAAVAAL
VADLPALTAV VHAAGAVDDG ILEGLDLPRT QAVLDAKVRA ARALHDATAG RDLDAFVLFS
SLAGVIGSAG QGNYAAANAF VDAFATWRHD LGLPATAVAW GAWAAEGMAA ASADLTARLV
RGGVHPLPAE QAAAALGRVV GAGPALTVAD VDWGRLAATR GRPAPLLTGL PGVPAGPAVV
TPAVVVGRSL PQLTELVRAQ VALVLGHPAG RPLPDRTFRD LGFDSLTAVE LRNRLAAETG
ATLPATLVFD HPTVAELAAH LHGLTADPTG GAVVAADVDR HREPVAIVAM SCRFPGGVAT
PEQLWELVAG GTDALSTMPQ ERGWNVAELY HPDPEHLGTS YVCEGGFLTG AGEFDPAFFG
ISPREAVAMD PQQRLLLETA WEAFERARLD PAGLRGSRTG VYVGTNGQDY GSLLLAAGDG
DENYLATGVS ASVISGRLAY TFGLHGPAVT VDTACSASLV ALHLAAQALQ AGECDLALAG
GATVMATPGI FVGFSRQRGL AADGRCKPFA GAADGTGWGE GVGLLVLQRL SDARRDGNPV
LAVVRGSAVN SDGASNGLTA PNGPAQQRVI RQALANAGLA PDQVDAVEAH GTGTTLGDPI
EAQALIATYG RDRDTDRPLW LGSVKSNLGH TQAAAGVAGV IKMVLAMRAG VLPPTLHVDE
PTPHVDWSAG TVALLTEARP WPAGDRPRRA AVSSFGISGT NVHTVLEQAP PEEPAPRDAV
PAGELPWTLS GRGTAALAAR ARDLRAHLDA VPDAALPDLA WSLATTRTAH EHRAVVLAAG
RDDLAAALDA LAAGRPAPHT VTRPPGTGGD VVFVFPGQGS QWTGMAADLL ATAPVFAETF
TACAQALRPH LDWSPVDVIR GAPDAPSLER VDVVQPTLFA VGVSLAALWR SYGVHPSAVV
GHSQGEIAAA YVAGGLSLDD AAAVVALRSR VIAEIAGDGG MVSVATTADE ATETIGRWDG
RVALAAVNGP TSVVVSGDAA ALDELIAHYQ GRDVRVRRVP VDYASHSAHV EPLRERLRDL
LAGLRPRTGD IRFRSTVTGD WTDTAGLDAD YWYRNLRQTV GFDAAIRDLA ATGHQTFVEV
SAHPVLTMAM QESVEAAAAD PTAVTVTGTL RRDEGDLARF HRALAEAYAG GVAVDWRPAF
AGLAARRLDL PTYPFQRQPY WPRPAAVPVA AAPVEPDEVD ARFWAAVEAE DPAAVGAELA
DTADVPADAL AALLPALAAW RRRHRDQATV DSWRYRDGWL PVAPDAADRP TLDGDWWLVT
GPGDLGVDAA DVVADALRRH GATVVPLALT GERTDRDALT ARLRDRHADA PPAAVVSLLA
LDETPLPAHR HVPAGYAGTV TLTQALGDAG IRAPLWTLTR GAVSTGPTDP LPHPTQQLAW
GFGRIAALEH PDRWGGLVDL PDTVDDRTAT RLARVLAGAD GEDQVALRPT GAYGRRLLRA
PLGDTPAPRD WRPTGTALVT GGTGALGGHV ARWLAAHGAD HLVLLSRRGR DGDGVDELEA
ELTALGARVT VAACDAADRD ALAAVLAGLP AEHPLTTVVH TAAVLDDAVI GALTLDRIDH
ALGAKVTAAV NLHELTRDHD LDAFVLFSAM AGTVGSSGVG NYAPGNAYLN ALAEHRRGLG
LPATSIAWGA WGGGGMADGE FGRMLHRHGA PEMHPRLAIA ALHQALAHDE TYLTVSNIAW
DRFRVALTAT RPAPLIAEIP EARQLAADRE PDETAEAAPA GAFARMASDE RREALLDLVR
DQAATVLKYA GGEAVDPHHA FRDLGFDSVT AVELRNRLAT ATGLRLPVTL VFDYPTATVL
ARHLHTELGG VAETGPAAGP TPLADDEPVA IVAMSCRFPG GVTDPERFWQ LLHAGRDAVS
DLPGDRGWDL DGLYDPDPYS AGTSYVRTGA FLYDVADFDA GFFGISPREA VAMDPQQRLL
LETSWEAIER AGVDPGGLRG SRTGVFVGTN GQDYGALLMV SADEVEGFAS TGNAASVVSG
RVAYVLGLEG PAVSVDTACS SSLVALHLAA AALQRGECDL ALAGGVTVMA TPGLFVEFSR
QRGLAPDGRC KAFAAAADGT GWGEGAGMLL VERLSDARRN GHPILAVLRG SAVNQDGASN
GLTAPNGPSQ QRVIRAALAA ARLSPADVDV VEAHGTGTTL GDPIEAQALI ATYGQGRADV
EPLLLGSVKS NIGHTQAAAG VAGVIKMVLA MRAGVVPPTL HVDAPSPHID WSAGAVELVT
ENRAWPAAGP RRAAVSSFGI SGTNAHVILE LPDETPADAA RPGPPAGADT ARSGLLDGAL
AWPVSARTRD GVARQAGRLA RHLRGTSADP AVIAWSLATT RSAFDHRAAV VGSSAKDLLS
GLDALAAGTP SPAVVTGTVA GRGAGPVFVF PGQGAQSARM AAGLVGRTPV FDATLADCQA
ALSPFLDVDL PSVLTGDDES WLDRVEVVQP VLWAVGVALA AVWRHVGVSP QAVIGHSQGE
IGAACVAGIL SLEDAARTVA LRSRALAALR GTGTMASVDL PADEVTARLE ADRATDGAVG
PDAVAPGDTD GAGRFSGVGI AAVNGPSTVV VSGPPQAVAD FVAACQADEV RARLIPVDYA
SHSAAVEEVA QRLRTDLADV APQPGHIRLV STLTGDWVDP ASMTADYWYD NLRRTVRFDT
AVRTAVGAGH STFVEISPHP VLAMPVTAIL DDTATTGHVL STLRRGDDDP TRLLTNLATA
HAVGLPVDLT RVLPETTTVD LPTYAFDRER YWPRTRTVDT ADAPTGADAA FWAAVDNEDL
AALADLTAQD ATESLDRLGA ALPLLADWRR RQRDRSTLDD LRYRAVWQPY AGVPVAFLTG
AWWVVADPDG IAEAETAVAE LTRRGADARL VLLPEDATDR AAVAARLTAA GAGPVDGVLS
LLALADTPAD APVPPFLARS LALLQALGDL DVPAPLWCVT RGAAGTTRDG GVGRPEQALL
WGLGRVAALE HPQRWGGLVD VPATLDDHGW DLLCAALSGP DGEDQLAVDG VTLLVRRLVR
APGGGADPAD GHPGTTLVTG GTGALGGQVA RWFADRGAAH LLLVSRRGAD APGAADLVRD
LTDRGARVTV AACDVADRAA LAKLLDDVPA DAPLTTVVHA AGVLDDGVLD GLTADRIADV
LRPKALGALH LHELTAEKDL RAFVLFSALP GQLGAAGQGS YAAANAYLDA LAEQRHRQGL
PATSVAWGPW ATGGMADADP AVAERRRRSG VTRLDADLAL TALAGCLTGR EPVTLIAGVD
WARYVPGFTA VRPSPLLTGI PEARRAAAER AEEGGPTADS LAALLAGQTD AERRRTVLDL
VRGQAAAVLG HASDAAVEPD RAFRDLGFDS LTAVELRNRL TAATGVRLPA TVVFDYPTAA
LLAEYVRAAV VDGGVAAATP VFGELERLEA ALAGAAPDRG ARLRITERLR TLLASLNEVD
APADGDGVAG KLQDATPDEV FDFIDRELGV S
//