ID A0A1A9BI09_9ACTN Unreviewed; 565 AA.
AC A0A1A9BI09;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=GA0070622_6264 {ECO:0000313|EMBL:SBT69145.1};
OS Micromonospora sediminicola.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=946078 {ECO:0000313|EMBL:SBT69145.1, ECO:0000313|Proteomes:UP000199558};
RN [1] {ECO:0000313|EMBL:SBT69145.1, ECO:0000313|Proteomes:UP000199558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45794 {ECO:0000313|EMBL:SBT69145.1,
RC ECO:0000313|Proteomes:UP000199558};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; FLRH01000004; SBT69145.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A9BI09; -.
DR STRING; 946078.GA0070622_6264; -.
DR Proteomes; UP000199558; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
FT DOMAIN 202..356
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 410..558
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 565 AA; 62210 MW; A6F6CF8AFE47411D CRC64;
MREDAGVSGG PLIVQSDKTL LLEIDHPDAQ ACRMAIAPFA ELERSPEHVH TYRLTPLGLW
NARAAGHDAE GVVDSLIKYS RYPVPHGLLV DVAETMDRYG RLQLANDPVH GLVLRALDRV
VLIEVAKSKK LAGMLGAKLD DDTIAVHPSE RGRLKQALLK LGWPAEDLAG YVDGEAHPID
LAESGKDGGR PWTLRSYQRE AVEAFWAGGS GVVVLPCGAG KTLVGAAAMA EAKATTLILV
TNTVAGRQWK RELIARTSLT EEEIGEYSGE RKEIRPVTIA TYQVLTSRRG GAFTHLDLFG
ARDWGLVVYD EVHLLPAPIF RFTADLQARR RLGLTATLVR EDGREGDVFS LIGPKRYDAP
WKDIEQQGWI APAECTEVRV TLTDAERMAY ATAEAEERYR MAATARTKLP VVRALVERHP
DEQVLVIGGF LDQLHQLGEY LDAPIVQGST TNKERERLFD AFRSGSLRTL VLSKVGNFSI
DLPEAAVAIQ VSGTFGSRQE EAQRLGRVLR PKADGRQAHF YTVVSRDTID TEYAAHRQRF
LAEQGYAYTI VDADDVLGPK LPTVD
//
