ID A0A1A9BMZ7_9ACTN Unreviewed; 337 AA.
AC A0A1A9BMZ7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Phosphoglycerate dehydrogenase {ECO:0000313|EMBL:SBT88924.1};
GN ORFNames=GA0115233_1005105 {ECO:0000313|EMBL:SBT88924.1};
OS Streptomyces sp. DI166.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839783 {ECO:0000313|EMBL:SBT88924.1, ECO:0000313|Proteomes:UP000198690};
RN [1] {ECO:0000313|EMBL:SBT88924.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DI166 {ECO:0000313|EMBL:SBT88924.1};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; FLSP01000005; SBT88924.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A9BMZ7; -.
DR STRING; 1839783.GA0115233_1005105; -.
DR Proteomes; UP000198690; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12167; 2-Hacid_dh_8; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000198690}.
FT DOMAIN 49..328
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 122..297
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 337 AA; 36301 MW; 220961DCA39390E6 CRC64;
MPSPQPPRAV FALDPVHLPQ LFPPPLMARL RRTADLDPAL VVRDFTDPSV AGALARADVL
ITGWGCPHLD ADALAAAPRL RAVLHSAGSV RSLIGDAVWE RGIGVSSAVA ANALPVAEYT
LAMILLTGKD AFTQRDRYRA THTQPSPTET AHIGNVGRRV GIIGASRVGR RLLELLRPFD
FEVLLHDPYV SEPEAAALGA QLVTLETLLS RSDIVSLHAP DLPETHRMLD APRLALIRDG
GVLINTSRGA LIDQEALTQE LIRGRLQAVL DVTTPEPLPP TDPLYDLPNV FLTPHIAGSL
GNELTRLGHI VTEELERVAT NSPLKHAVTQ SDMTRVA
//
